One of our life philosophies? Do more with less. That includes less coffee, less booze, and less forced stimuli to feel like our best selves, resulting in more headspace for you and others.
That is why we are delighted to introduce our first Unstress Stack: The Calm and Clear Duo, the latest addition to our collection of focus-enhancers, nootropics, and neurotrophics. We curated this regimen for those that deal with constant feelings of stress, brain fog, low mood, and anxiety. If you're looking to cut down on the jitters that come from coffee, or the dullness that come from alcohol, this set is for you.
Why the Calm and Clear Duo?
Stress reveals itself in myriad ways, and it can be different for every person and change over time. Ongoing stress triggers increased cortisol, which can impact your mood, brain, sleep, hormones, skin, gut, and immunity.
This is because stress results in failure of homeostasis, leading to various imbalances and diseases. A whopping 75%–90% of human disease is related to the activation of our stress-regulating systems, though the common pathways between stress exposure and pathophysiological processes underlying disease are still debatable. In fact, chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggests that excessive inflammation plays a critical role in the pathophysiology of stress-related diseases.
While the stress response is perfectly normal and vital to living a healthy life, prolonged stress triggers high levels of cortisol, the stress hormone, which can cause damage throughout the body but particularly to the brain. In short spurts, cortisol can improve cognitive function and boost your immunity by limiting inflammation. However, your body will build a tolerance to cortisol if you have consistently high levels of the hormone, which can lead to inflammation and a weakened immune system.
Cortisol has also been shown to actually decrease cognition by causing memory loss as well as shrinkage of brain matter. It is also responsible for poor sleep, further exacerbating deteriorating functional connectivity in the brain. This is why balancing CBD, brain-boosting psilocybin, stress-busting adaptogens, and nutrient- and antioxidant-rich rich superfoods can have a significant impact on your brain health.
The Calm and Clear Duo delivers an intelligent blend of organic full-spectrum hemp-extracted CBD, Psilocybe Cubensis, Lion's Mane, Sage, Cinnamon, and Vitamin B3 (as Niacin), 100% plant-sourced to support cognitive function, stress, and hormonal balance.
What's in the Calm and Clear Duo, and who's it for?
Whether you're looking to get back what you've lost or take yourself to the next level, read on to learn about the clinically-backed benefits of each ingredient, and how they work better together to give you a "Limitless"-esque edge.
CBD's Brain Benefits
Multi-dimensional CBD interacts with a range of molecular targets with functions that benefit your brain, from establishing homeostasis (or balance) to increasing serotonin 5-HT1A receptor expression.
CBD increases endocannabinoid signaling and tones the ECS (endocannabinoid system), your master regulatory system, to help regulate homeostatic processes in the body that promote balance across key systems responsible for sleep, mood, immunity, pain, gut health, and more—including the inflammatory immune response, a stressed nervous system, and overactive HPA (hypothalamic-pituitary-adrenal) Axis. By supporting homeostatic processes, CBD has been shown to reduce cortisol levels and help establish hormonal balance.
CBD relieves anxiety and depression, improves mood, and brings calming energy by activating serotonin 5-HT1A receptors, and protects the brain by exerting powerful antioxidant, anti-inflammatory, and neuroprotective benefits.
Recent preclinical studies have also shown that CBD also promotes neuroplasticity, as well as neurogenesis in the hippocampus.
Neuroplasticity, also known as neural plasticity, synaptic plasticity, or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization. It is when the brain is rewired to function in some way that differs from how it previously functioned. Neurogenesis is the process that generates new neurons. The hippocampus plays a major role in memory, cognition, organization, and learning. Together, these processes increase brain network density and improve functional connectivity in the brain.
Ultimately, the accumulative benefits of CBD help to relieve low moods, anxiety, and energy levels while leading to transformational changes in memory, focus, processing, and mental resilience.
Psilocybin's Brain Benefits
Multi-tasking psilocybin, found in Brain Stack, promotes neuroplasticity, neurogenesis, and synaptogenesis, functions that are critical to the creation, growth, and maintenance of brain networks in both the hippocampus and the PFC (pre-frontal cortex). It also exhibits potent anti-inflammatory benefits, helping protect your brain from inflammation and neurodegenerative disease, such as Alzheimer's. It exerts its profound effects on the mind by interacting with a serotonin receptor in the brain called 5HT-2A. This receptor can also be found in almost all other parts of the body, including immune-related structures like the spleen and white blood cells.
Note that CBD and psilocybin interact with different serotonin receptors. CBD indirectly interacts with the 5-HT1A receptor, which is involved in the mechanism of action of anxiolytic (anxiety-relieving), antidepressant, and antipsychotic medications. Psilocybin interacts with serotonin 5-HT2A receptors (5-HT2ARs), which are widely distributed in the central nervous system, especially in brain regions essential for learning and cognition.
Adaptogenic Lion's Mane's Brain Benefits
Adaptogens help reduce the exaggerated response to stress, which results in improved focus and attention, less mental fatigue and anxiety, better quality sleep, and a generally healthier brain.
Lion's Mane in particular, found in Brain Stack, is a nootropic adaptogenic mushroom with profound brain-supporting benefits. Preclinical studies suggest that Lion's mane may reduce inflammation and biological markers of Alzheimer's (i.e., amyloid plaques), improve cognition, and increase the release of nerve growth factor, a protein that can increase the length of nerve cell processes.
Superfoods Cinnamon and Sage's Brain Benefits
Cinnamon provides benefits that include reduced inflammation, improved memory, increased attention, and enhanced cognitive processing, while Sage can help support your brain and memory in several ways. For one, it's loaded with compounds that can act as antioxidants, which have been shown to buffer your brain's defense system. It also appears to halt the breakdown of the chemical messenger acetylcholine (ACH), which has a role in memory.
Vitamin B3's Brain Benefits
Your brain needs niacin—as a part of the coenzymes NAD and NADP—to get energy and function properly.
Vitamin B3 supports proper brain functioning, and a severe deficiency has been associated with dementia, leading some researchers to believe that getting enough in your diet is crucial to the prevention of Alzheimer's disease. Deficiency has also been associated with symptoms of psychosis, and supplemental nicotinic acid and nicotinamide, different forms of Vitamin B3, have been used to treat schizophrenia.
Vitamin B3 is also an essential building block in the energy production process. Ironically, drinking too much caffeine depletes your B vitamins, leading to the inevitable crash.
Pretty fly for a fungi.
The best time to plant a tree is yesterday. The second best is today.
Create more headspace and kickstart new habits with our first Unstress Stack → Calm and Clear Duo, a new type of calming and clarifying brain boost that doesn’t tote the inevitable mid-afternoon crash and burn that coffee does. This caffeine-free plant-sourced blend sources its energy from its stress-reducing and brain cell-regenerating functions. Because we believe optimal health should be accessible, you save 35% by purchasing this set.
While humans have used these powerful mushrooms and plants for thousands of years to treat and cure diseases of both the body and mind, it’s only been in recent history that they’ve wiggled their way into mainstream culture. Our goal is to continue to research, design, and deliver multi-tasking personal care products that are functional, minimal, clean, and sensibly priced. We'd recommend incorporating them into your existing daily regimen through daily practices that, while simple, lead to transformational results.
You have no idea how good your body was designed to feel.
As co-founder, I'd like to leave you this note:
We've been using plants as medicine for over 10,000 years, and mushrooms themselves are more closely related to us than they are to plants genetically. We went wrong somewhere along the way, around the time that the modern Western pharmacopeia was codified, but we're seeing a renaissance thanks to the monumental effort of the brightest scientists, researchers, and authors doing the work—providing clinically-backed evidence for what we've long assumed about these magical little plants and fungi. They're packed with micro-, macro, and myco-nutrients that are essential to our healing and functioning—and we're only just scratching the surface."