CBD isolate is a purified form of cannabidiol (CBD). Unlike full-spectrum CBD products, CBD isolate does not contain any THC—the intoxicating component of cannabis.
CBD isolate is cannabidiol (CBD) with all the other cannabinoids, terpenes, and compounds removed. This includes delta-9 tetrahydrocannabinol (THC), the cannabinoid responsible for the mind-altering “high” feeling often associated with cannabis use. Compared to full-spectrum CBD and broad-spectrum CBD, which have trace amounts of other cannabinoids, CBD isolate is a single-molecule material that may share many of the same benefits.
CBD isolate is a good option for you if you would like to try CBD, but cannot or do not want to ingest any tetrahydrocannabinol (THC).
Keep reading to learn more about CBD isolate, including how it's made, its potential health benefits, how to use it, and possible side effects.
What is CBD isolate?
CBD, a cannabinoid, is what we like to call a neuro-adaptogen. Like adaptogens, it has the ability to regulate the stress response and balance cortisol levels. Unlike most adaptogens, it has a range of benefits that also support cognitive function, long-term brain health, and overall health & well-being.
In its purest form, CBD isolate is a crystalline solid or powder made of pure CBD. It is then generally added to beverages, oils, and edibles to make it easier to consume. Unlike CBD isolate, full-spectrum CBD products can legally contain up to 0.3% THC. This amount of THC may show up on a drug test, but will not cause a high.
Full-spectrum and broad-spectrum CBD products also contain a wide range of cannabinoids, terpenes, and other naturally occurring compounds found in the hemp plant that work together to create what’s proposed as the entourage effect—the theory that consuming CBD and THC with other naturally occurring cannabinoids together has a greater effect than taking them separately. However, research is still determining to what extent this is true.
To produce CBD isolate, manufacturers use various processes to extract all the compounds and other substances from the cannabis plant, including THC. The process leaves behind pure CBD in crystal form.
Manufacturers may then grind the crystals into a powder, and then introduce that powder to an oil or edible to make the product easier to consume. CBD isolate does not have a distinctive smell or taste.
Effects of CBD isolate.
CBD is a neuro-adaptogenic cannabinoid that works by acting on the cannabinoid receptors in the brain and body. These receptors exist because the human body produces its own cannabinoids, called endocannabinoids, which interact with the ECS to regulate several bodily functions, including:
- brain function
- stress response
- immune function
- pain perception
CBD isolate vs. full-spectrum CBD.
Results from the study indicate that CBD isolate is also only effective against pain and swelling at a specific dose. Meanwhile, full-spectrum CBD products provide increasing effects as the dosage increases.
There's also other research demonstrating full-spectrum CBD's superior effects.
In 2022, researchers published results from a clinical trial indicating that taking a high-CBD (full-spectrum) sublingual product for 4 weeks effectively reduces moderate-to-severe anxiety. Patients experienced significant anxiety reduction within a week, with all achieving and maintaining treatment response by week 3; this is notably faster than conventional pharmacotherapy which can take up to 12 weeks.
Notably, treatment response was achieved with a much lower dose (~30 mg/day) in this trial compared to a previous one using a single CBD isolate (~300 mg/day).
A 2022 case study showed that pure CBD worked well for treating autism spectrum disorder (ASD) in childhood but stopped being effective during puberty, leading to increased hyperactivity and aggression. The solution was enriching CBD with a specific blend of calming terpenes, creating a broad-spectrum CBD that significantly reduced aggressive behavior.
Importantly, this improvement was achieved with less than half the amount of CBD used in the pure CBD treatment (0.19mg/kg vs. 0.48mg/kg, respectively).
A meta-analysis published in the peer-reviewed journal Frontiers in Psychology revealed that patients with refractory epilepsy needed lower average doses when treated with full-spectrum, high-CBD products compared to single extracted CBD isolates. Patients using CBD-rich extracts had a lower average dose (6.0 mg/kg/day) compared to those using purified CBD (25.3 mg/kg/day). For somebody weighing 70kg, that's 420mg of full-spectrum CBD vs. 1,771mg of CBD isolate.
These differences might be linked to the "entourage effect," where the combined action of various compounds, including cannabinoids, terpenoids, and flavonoids, can enhance the overall effects of cannabinoids when they work together synergistically.
That said, CBD isolate is still a useful option for people who must refrain from having any THC in their system, or for those who do not need a full-spectrum CBD product.
Uses and benefits of CBD isolate.
Although CBD isolate contains exclusively CBD, it may share many similar benefits to full-spectrum CBD and broad-spectrum CBD.
As a neuro-adaptogenic compound, CBD lightly touches dozens of pathways to exert its effects. Which is why it's helpful for such a diverse range of conditions.
Daily use of CBD can lead to improvements in energy, mood, and focus. The ability of CBD to balance our stress response and inflammation is a great benefit for our gut and mood, with many people also experiencing reduced nausea and vomiting, as well as relaxed muscle tension.
A 2015 study in Neurotherapeutics suggests that CBD has the potential to treat anxiety disorders via a range of actions, including a decrease in autonomic arousal (heart palpitations or increased heart rate) and a reduction in conditioned fear responses (known as fear extinction). However, the specific role of CBD isolate in these effects is yet to be determined by research.
In addition, a 2019 case series in the Journal of Alternative and Complementary Medicine studying the effects of individualized doses of CBD (a capsule or liquid spray was decided by the provider and patient) on post-traumatic stress disorder (PTSD) found that among 11 patients, 91% reported a decrease in symptoms after eight weeks.
Here are some of the main ways that CBD is studied to optimize your health & well-being:
Regulates stress response.
In addition to balancing inflammation, regulating the stress response may be one of the most important benefits of CBD. Your ECS's role in regulating the proper functioning of all your other systems means your ECS also regulates your stress response. However, prolonged stress can overwhelm your ECS, disrupting the proper functioning of every system in the body and leading to catastrophic health consequences.
For example, by overwhelming the ECS, stress can promote:
- inflammatory diseases such as asthma, eczema or urticaria, rheumatoid arthritis, ulcerative colitis, and sickness syndrome
- pain disorders such as headaches and abdominal, pelvic, and lower back pain
- gastrointestinal dysfunction such as diarrhea, constipation, and peptic ulcers
- mental illnesses such as anxiety, depression, psychosis, cognitive dysfunction, and insomnia
- metabolic diseases such as diabetes mellitus, hypercholesterolemia, visceral obesity, and sarcopenia
- ischemic heart disease
- neurodegenerative diseases
- osteopenia and osteoporosis
CBD has been found to effectively enhance your endocannabinoid control of stress and combat stress and its manifestations (depression, anxiety, burnout, fear).
There have been seven double-blind placebo-controlled clinical trials on CBD for stress. All showed that CBD was effective in significantly reducing the stress response and its manifestations (anxiety, fear, depression, and burnout), and was non-inferior to pharmaceutical comparators when included.
These studies used an average of 150 - 300mg of CBD. However, your body chemistry is unique to you, so start with 50mg and work your way up as needed.
CBD may treat depression through several mechanisms:
- Activating serotonin: CBD can modulate serotonin receptors (5-HT1A), which play a role in cognition, mood, memory, pain, inflammation, and more. By enhancing serotonin signaling, it may help alleviate symptoms of depression.
- Increase in BDNF: CBD has been shown to promote the production of Brain-Derived Neurotrophic Factor (BDNF). BDNF plays a crucial role in promoting neuroplasticity, which can counteract the brain changes associated with depression.
- Reduction of Neuroinflammation: CBD possesses anti-inflammatory properties and can reduce neuroinflammation. Chronic inflammation in the brain is associated with depression, and CBD's anti-inflammatory effects may help alleviate depressive symptoms.
- Combating Oxidative Stress: CBD acts as an antioxidant, boosts our innate antioxidant defenses, and can combat oxidative stress in the brain. Excessive oxidative stress has been implicated in depression, and reducing it may contribute to symptom relief.
- Inhibition of the Stress Response: CBD has been found to reduce the body's stress response by interacting with the endocannabinoid system. This can lead to decreased feelings of anxiety and stress, which are often comorbid with depression.
These mechanisms collectively contribute to the potential of CBD to reduce depression by influencing neurotransmitter systems, promoting neuroplasticity, reducing inflammation, combating oxidative stress, and modulating stress responses in the body.
In clinical settings, several human studies show that CBD oil may significantly reduce depressive and psychotic symptoms in cannabis users, as well as improve memory and cognitive functions. Nabiximols, used during cannabis withdrawal, also reduced depression. Additionally, a 2014 survey of 2,409 CBD users reported mood improvement in various medical conditions, though it didn't differentiate between pure CBD and marijuana-derived CBD products.
However, further research is needed to fully understand the extent of CBD's effectiveness in treating depression and its long-term effects. Always consult a healthcare professional before using CBD as a treatment for depression.
May treat bipolar depression.
In a study involving 35 participants, both placebo and cannabidiol (CBD) reduced Montgomery-Åsberg Depression Rating Scale (MADRS) scores for bipolar depression, with no significant difference between the groups. However, an exploratory analysis revealed that a higher dose of CBD (300 mg/day) showed a significant effect in reducing MADRS scores from week 2 to week 8.
No significant differences in adverse effects or manic symptoms were observed. Despite the primary outcome not being significant, further research with higher CBD doses (at least 300 mg/day) and improved placebo control is recommended for bipolar depression treatment.
Numerous studies indicate that CBD has anti-anxiety effects.
It likely works by changing the way the brain responds to the chemical serotonin, and by reducing activity in the amygdala. Neuroimaging studies suggest that CBD's anxiolytic effects could be related to altered brain connectivity between the anterior cingulate cortex and amygdala. This facilitates a process called fear extinction, which is when you no longer respond fearfully to stressful triggers.
Subsequent research in the 1990s indicated that CBD reduced anxiety during the simulated public speaking test and increased mental sedation in healthy subjects.
In 2011, researchers found that CBD reduced subjective anxiety in patients with social anxiety disorder (SAD) and improved sleep disturbances in psychiatric patients. However, in non-clinical volunteers with high paranoid traits, CBD increased anxiety and had no effects on persecutory ideation.
A 2019 study, for example, explored whether CBD improves sleep or anxiety, or both. The researchers reviewed the charts of 72 adults who had anxiety or sleeping problems at a psychiatric clinic. The researchers found that after CBD treatment, 79% of the participants reported decreased anxiety. Almost 67% of people saw improved sleep scores within the first month, but these fluctuated over time.
The researchers conclude that CBD may benefit those with anxiety disorders and that most people tolerate it well.
Another 2019 study suggests that CBD significantly decreased anxiety in teenagers with social anxiety.
CBD also showed promise in reducing anxiety and craving in heroin users in a 2019 clinical trial.
Ongoing trials are evaluating CBD's effects on anxiety in adults, including those with generalized anxiety disorder, social anxiety disorder, panic disorder, and agoraphobia.
Overall, these studies indicate that CBD has the potential to reduce anxiety, but its efficacy may vary depending on the specific population and circumstances.
Pain and inflammation relief.
People often use CBD to treat a variety of inflammatory conditions and types of pain, including:
- arthritis pain
- cancer pain
- chronic back pain
- neuropathic pain
While CBD isolate may provide pain relief, research indicates that a full-spectrum CBD product may be even more effective because cannabidiol acts synergistically with THC to boost its analgesic effects. Numerous studies assert that CBD works better with THC in most contexts, but this rings especially true for managing pain.
CBD demonstrates antiseizure effects, which means it has the potential to treat epilepsy. According to the American Epilepsy Society, CBD research offers hope for those with the condition.
A 2017 study cites strong evidence to indicate that CBD improves seizure control in those with specific epilepsy syndromes.
However, research is still in its early stages, and much more exploration is necessary before people with epilepsy can take CBD as a reliable source of symptom management.
Those who have epilepsy should discuss their treatment options with a doctor or healthcare provider.
Combats cancer and the effects of cancer treatment.
Cannabinoid receptors are found on both cancer and normal cells. Dysregulation of the endocannabinoid system (ECS) is associated with various diseases, including cancer, and symptoms related to cancer and its treatment, like anxiety, depression, and sleep disturbances.
In a 2021 study on cancer and cannabinoids, Mangal and colleagues note that the endocannabinoid system (ECS) plays a specific role in different types of cancer and emphasize that cancer is a heterogeneous disease. Therefore, changes in the ECS may not be uniform across all cancer types. Additionally, since the ECS is involved in maintaining body homeostasis, it raises the question of whether elevated levels of endocannabinoids are a part of the disease's development or a response by the body to restore balance.
Several preclinical studies, including cell line experiments and animal models, have shown that various cannabinoids, such as endocannabinoids AEA (anandamide), 2-AG, phytocannabinoids THC, CBD, and synthetic cannabinoid receptor agonists, exhibit anti-cancer properties. These cannabinoids target multiple aspects of the "hallmarks of cancer," suggesting their potential in cancer therapy.
For example, CBD has shown promise in inhibiting the progression of various cancer types in animal models. This includes glioblastoma (GBM), breast, lung, prostate, colon cancer, and melanoma. In a melanoma mouse model, CBD treatment led to a significant reduction in tumor size compared to a placebo, ultimately increasing survival rates.
CBD also affects various tumor features and molecular pathways, possibly due to its multiple targets. Much of its anti-tumor activity is attributed to its regulation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and immune modulation, all of which are crucial in tumorigenesis.
It's worth noting that most animal studies use isolated CBD or THC. However, there is a need for more research comparing the effects of CBD isolate and whole-plant (full-spectrum) CBD medicines. Isolates and full-spectrum CBD may behave differently.
For instance, a study by Gallily and colleagues found that when studying the pain-relieving and anti-inflammatory effects of CBD in rodents, the dose-response curve for CBD isolate looked like a bell or a U-shape. In contrast, the full-spectrum CBD extract showed a linear curve, meaning the effect increased with the dosage. This indicates that the choice between isolate and full-spectrum CBD can significantly influence the observed outcomes.
The Canadian Cancer Society indicates that CBD is a complementary therapy that may alleviate some cancer symptoms and side effects of cancer treatment (including nausea and vomiting).
How does CBD isolate work?
CBD lightly touches dozens of systems to deliver its therapeutic benefits. However, there are a few that deliver the bulk of the results: the endocannabinoid system (ECS) and the serotonergic system.
Research suggests that plant-based cannabinoids like CBD isolate interact with the body’s ECS, which is responsible for regulating many physiological processes, including the stress response, cognitive function, pain, inflammation, and immune response.
Cannabinoids work in the human body by binding to cannabinoid receptors in the ECS called CB1 and CB2 receptors. These interactions can help regulate the body’s central nervous system, emotional response, and immune response, among other functions.
The ECS is arguably one of the most important systems in your body, and this has been recognized by the scientific community.
In 2022, GSC Biological and Pharmaceutical Sciences called the ECS the "single most important scientific medical discovery since the recognition of surgical techniques. As our understanding of its complexities expands, it becomes increasingly evident that the endocannabinoid system controls all physiological and psychological processes."
In 2019, Cerebrum called the ECS "one of the most important physiologic systems involved in establishing and maintaining human health."
CBD also interacts with serotonin receptors, namely serotonin 5-HT1A. This interaction leads to healthy serotonin activity, which in turn leads to an increase in BDNF (Brain-Derived Neurotrophic Factor). BDNF is like Miracle-Gro for the brain, helping to increase the pool of neurons and stimulate new, healthy connections between them.
The role of endocannabinoids.
Endocannabinoids regulate the processes listed above by interacting with CB1 and CB2 receptors, which are found throughout your immune and nervous systems, including your brain.
Researchers believe that CBD does not attach directly to these receptors; instead, it influences them by increasing your endocannabinoid levels, which is referred to in clinical literature as "enhancing your endocannabinoid tone." In addition to their numerous other roles, some of which we listed above, their primary role is to balance your stress response and support healthy inflammation through your endocannabinoid system (ECS).
Endocannabinoid receptors are located in just about every system in your body. That's because your ECS is responsible for regulating and balancing all your other systems, including your nervous system (brain and nerves), endocrine system (hormones), and immune system. Because of its role as a master conductor, it's arguably the most important system in your body, and keeping it toned is directly correlated with resilience to stress and disease.
However, stress, poor sleep, and toxins can overwhelm the ECS, which can lead to anxiety, depression, gut issues, inflammatory conditions, neurodegenerative disease, and more.
What is the endocannabinoid system (ECS)?
The ECS plays several primary roles in the body, including:
- Regulation of Homeostasis: The ECS helps maintain a stable internal environment, or homeostasis, by regulating various bodily functions such as temperature, pH balance, and fluid levels.
- Neurotransmitter Regulation: It modulates the release of neurotransmitters, including serotonin and dopamine, which are crucial for mood, appetite, and overall mental well-being.
- Stress Response: The ECS helps the body adapt to stress and regulates the release of stress hormones.
- Pain Perception: The ECS influences how the body perceives and manages pain, making it an important target for pain management and relief.
- Inflammation Control: It plays a role in regulating the body's inflammatory response, which is essential for the immune system's proper functioning.
- Immune System Modulation: The ECS helps in balancing immune system activity and responding to infections and diseases.
- Neuroprotection: It is involved in the protection of nerve cells, which can be important for conditions like Alzheimer's and Parkinson's disease.
- Metabolism and Appetite Regulation: The ECS influences appetite and metabolic processes, which has implications for weight management and related disorders.
- Memory and Learning: It plays a role in memory formation and cognitive processes.
Overall, the ECS is a complex system that helps regulate numerous physiological processes, maintaining the body's balance and promoting overall health and well-being.
Signs of an impaired ECS.
A weakened endocannabinoid system (ECS) can be caused by various factors, including genetics, chronic stress, aging, poor diet, lack of physical activity, chronic illness, medications, and exposure to environmental toxins.
Manifestations of a weak ECS may include:
- Stress Sensitivity: An exaggerated stress response reduces your ability to cope with stress and its associated physical, emotional, mental, and hormonal effects.
- Mood Imbalances: Increased susceptibility to mood disorders like anxiety and depression.
- Imbalanced Immune System: Greater vulnerability to infections and immune-related issues, such as autoimmune disease.
- Inflammation: An increased inflammatory response.
- Difficulty Managing Pain: Reduced ability to control pain and discomfort.
- Sleep Problems: Difficulty in achieving restful sleep.
- Appetite Irregularities: Changes in appetite, possibly leading to weight management issues.
- Cognitive Problems: Impaired memory and learning.
CBD supports and enhances ECS function.
Supplementing with CBD can restore your ECS tone and function, which is how CBD exerts its effects on the human body.
By restoring and enhancing ECS function, CBD's effects include:
- balancing the immune system (immune-modulating)
- counteracting the formation of tumors (anti-tumorigenic)
- supporting healthy inflammation (anti-inflammatory)
- supporting gut microbiota and overall gut health
- preventing vomiting (antiemetic)
- recovery or regeneration of the nervous system (neuroprotective)
- reducing or preventing anxiety (anti-anxiety)
- reducing or preventing seizures (anticonvulsant)
- relieving pain (analgesic)
CBD also promotes healthy serotonin activity.
Studies indicate that CBD can also influence non-cannabinoid receptors, such as the 5-Hydroxytryptophan (5-HTP) serotonin receptor—particularly 5-HT1A. Serotonin is a chemical that affects levels of depression, anxiety, and sleeplessness, among others. 5-HT1A is especially interesting as it is thought to not only influence mood and cognition but also influence the levels of other serotonin sub-types. This is one pathway that helps explain why CBD eases anxiety and pain in some people.
Furthermore, single-extracted CBD products were linked to more frequent reports of mild and severe side effects than full-spectrum, high-CBD products.
CBD may interact with certain drugs and medications, including anti-epileptic drugs, antidepressants, opioids, and substances like alcohol, as well as cause stomach upset in the form of diarrhea and vomiting, according to a study in Current Neuropharmacology, but this research did not explore CBD isolate specifically.
It can also interact with some dietary supplements. Individuals should take care if their medications or supplements carry a warning about grapefruit. Common examples include cholesterol drugs, such as atorvastatin (Lipitor) and others.
Both grapefruit and CBD can interfere with the metabolism of these medications. Anyone taking medication or supplements that carry a grapefruit warning should avoid CBD as well.
One study in mice indicated that CBD might also increase the risk of liver toxicity if taken in significant quantities. Anyone considering using CBD should talk to their doctor or one who specializes in CBD to evaluate their risk.
How to use CBD isolate.
Tinctures (sublingual oils):
Tinctures are oils that are taken sublingually, by dropping them under your tongue. CBD isolate tinctures are a popular choice if you're seeking rapid onset and precise dosing. They're more bioavailable, you feel the effects more quickly, and it's easy to adjust your dose as needed. You can even use them to make tonics and elixirs, like a soothing cup of CBD tea for calming your anxiety, or take advantage of their versatility by making yourself a protective, hydrating lip balm.
Here's how to use CBD isolate oils:
- Select the Right Tincture: First, choose a CBD tincture that suits your needs. You can find tinctures with various CBD isolate concentrations. My Supply Co.'s Isolate tincture contains clinical-level actives of organic hemp-extracted CBD isolate.
- Dosing: CBD oils come with a dropper; ours have measurements marked on the dropper, making it easy to control your dosage. To use, squeeze the bulb at the top of the dropper to draw the liquid into the pipette. Our CBD Dosage Calculator is designed to help you find an introductory dose based on your health goals or concerns, but you can refer to our guide to finding your ideal CBD dosage for additional context and the science. Increase gradually until you achieve your desired effect.
- Administration: Lift your tongue and place the desired number of drops (as determined by your dosage) under your tongue. Ensure the liquid is placed directly on the mucous membranes. Hold the tincture under your tongue for about 90 seconds before swallowing. This allows for better absorption straight into your bloodstream through the tiny blood vessels under your tongue.
- Timing: You can expect the effects to start within 15-30 minutes, making sublingual tinctures a suitable choice when you need rapid relief.
Pros of using CBD isolate oils:
- Rapid onset: Sublingual administration allows CBD to be absorbed directly into the bloodstream through the mucous membranes under the tongue. This leads to quicker onset, typically within 15-30 minutes.
- Higher bioavailability: Sublingual tinctures offer higher bioavailability as they bypass the digestive system, allowing for more efficient absorption of CBD.
- Easy dosing: Tinctures often come with droppers, making it simple to measure and adjust your dosage as needed.
Cons of using CBD isolate oils:
- Taste and texture: Some people may find the taste or texture of sublingual tinctures less appealing.
CBD edibles offer a convenient and tasty way to consume CBD, but they have a slower onset time compared to tinctures. Here's how to use them:
- Choose the Right Edible: Edibles come in various forms, such as gummies, chocolates, capsules, and more. Select an edible product that appeals to your taste and dietary preferences. Check the product label for the CBD content per serving.
- Dosing: Edibles are much less bioavailable than tinctures, so you have to take more to achieve the same effects. Where tinctures have a bioavailability of 50%+, edibles have a bioavailability of 4%+. Note that this rule only applies to CBD edibles. With THC edibles, you want to start with as little as 5mg of THC, as your liver converts THC into a compound that is five times more powerful than THC.
- Ingestion: Simply eat the edible as you would any other food item. The CBD will be absorbed through your digestive system. Edibles take longer to produce effects, often ranging from 30 minutes to 2 hours, so be patient and avoid taking additional doses too quickly.
- Duration: Edibles are known for their longer-lasting effects, which can extend up to several hours. This makes them a suitable option for maintaining a consistent CBD level in your system throughout the day.
Pros of using CBD isolate edibles:
- Longer-lasting effects: Edibles undergo a slower digestion process, leading to prolonged CBD release into the bloodstream. This can result in longer-lasting relief from symptoms.
- Taste and variety: Edibles come in various forms, from gummies and chocolates to capsules and beverages, making them an appealing choice for those who prefer a more pleasant taste or different flavors.
- Precise dosing: Many edible products offer precise dosing information, allowing users to control their CBD intake more accurately.
Cons of using CBD isolate edibles:
- Slower onset: Edibles can take longer to produce noticeable effects, typically between 30 minutes to 2 hours, as the CBD has to pass through the digestive system.
- Lower bioavailability: A significant portion of CBD is lost during digestion, resulting in lower bioavailability compared to sublingual tinctures.
- Inconsistent effects: Individual metabolism and food in the stomach can affect the absorption and consistency of effects.
Keep in mind that individual responses to CBD can vary, so it may take some experimentation to find the optimal dosage and form that works best for you.
In summary, we recommend using CBD oils, or tinctures, sublingually for their higher bioavailability, precise dosing, and fast-acting effects.
CBD isolate is generally a low-risk substance, especially as it does not contain THC.
Epidiolex, an FDA-approved drug containing CBD isolate used to treat rare and serious forms of epilepsy and contains CBD isolate, may induce side effects of fatigue, decreased appetite, and increased liver enzymes, according to the FDA. A trial in Clinical Pharmacology and Therapeutics concludes that liver enzymes are more likely to increase when a person is consuming high doses (around 1,500 milligrams of CBD per day). The same trial proposes these effects may not cause serious or long-term liver damage.
However, in some people, it may cause adverse reactions that include:
- an increase or decrease in appetite
- weight loss or weight gain
Summing it up.
CBD isolate offers an alternative to full-spectrum CBD products. It may be especially useful for those who would like to try CBD without ingesting any of the intoxicating compound, THC.
CBD isolate demonstrates several benefits, including relief from pain, inflammation, and anxiety.
Research indicates that some of these benefits may be more pronounced when taking a full-spectrum CBD product, however.
When choosing a CBD isolate, always buy from a reputable company and read the label carefully to ensure it is free from THC, other chemicals, and impurities.