• What's the main factor in choosing a strain of magic mushrooms?

    When choosing a strain of magic mushrooms, the most important factor is strength. Some strains are considered stronger than others, but overall the effects are more or less the same if you select a strain from the Psilocybe cubensis species.

  • How can you use magic mushrooms for depression?

    There's some anecdotal evidence and a small amount of research that suggests microdosing may be the best way to use magic mushrooms for depression.

  • How can you use magic mushrooms for anxiety?

    According to anecdotal evidence and some research, taking a single macrodose might be the best for anxiety. It's the same for addiction and for traumatic brain injuries.

  • Tips on using magic mushrooms therapeutically?

    Be sure to include your doctor or therapist in your decisions to use magic mushrooms. If you're inclined, or it's your first time, have a trip-sitter or spiritual guide attend your journey to assist.

We’ve received a lot of questions regarding how to choose a mushroom strain and how to use different strains of magic mushrooms for different therapeutic purposes. Some of you might be using magic mushrooms for depression, others for anxiety, and others might be battling through some existential crisis.

So, we took the pleasure of compiling as much anecdotal information as we could from Shroomery and Erowid.

This aspect of magic mushrooms is pretty much neglected in clinical research, so we have to preface this by saying that none of the information in this article is backed up by science. It all comes from the anecdotes of the many mushroom users who have come before us.

When it comes to science, we’ve come to understand a little about how different species of magic mushrooms are composed.

That is to say — different strains of magic mushrooms might have different ratios of psilocybin, psilocin, and other hallucinogenic alkaloids, but we don’t know to what degree this affects the experience. Or how it affects the therapeutic potential.

As we have mentioned a number of times across our blog posts on magic mushrooms, the biological effects of magic mushrooms aren’t necessarily what’s thought to be therapeutic. Rather, both anecdotal and clinical evidence demonstrates that the subjective experience might be a driver of the therapeutic potential of psilocybin mushrooms. 

In this article, we’ll outline the common effects of some of the more common and most popular strains of magic mushrooms.

Then, we’ll talk about how to use magic mushrooms for some of the most common reasons people seek out their therapy. Let’s dive in.

How to choose a strain of magic mushrooms.

A collage art of a woman with the galaxy surrounding her head and stars in the background. A concept image of magic mushroom strains.

When it comes to choosing which strain you’re going to use — and given how little we know about different therapeutic effects — you should mainly be choosing based on strength. Do you want to have a really strong magic mushroom experience; will you be macrodosing or microdosing; would you prefer something a little more gentle?

Read: The Ultimate Guide to Magic Mushroom Microdosing

Read: The Ultimate Magic Mushroom Dosage Guide

If there’s one thing that really separates different strains of magic mushrooms, it’s strength.

Some psilocybin mushrooms are known for being more potent than others. You might consider using a stronger strain of magic mushrooms if you’ll be macrodosing. You might also choose a stronger strain so that you can eat less and avoid any nausea.

There is some anecdotal evidence that the trips produced by certain strains are different.

For example, one user on Shroomery reported having a “unique spiritual experience” using African Transkei magic mushrooms. In another thread, users report that B+ magic mushrooms have a stronger body load and less visual effects. 

You’ll often hear from magic mushroom users that “a cube is a cube.”

This basically means that if it’s a magic mushroom of the species Psilocybe cubensis (most of the mushroom strains at My Supply Co. and in dispensaries are cubensis species), then its effects are more or less the same.

With that in mind — and given that the subjective experience drives mushroom's long-term benefits — choosing a strain shouldn’t be that hard.

Macrodosing and microdosing can both be done with strong and weaker strains, but you might want to consider weaker mushrooms for microdosing to stay safe.

We recommend the following magic mushrooms for stronger journeys:

  1. Blue Meanies (also available as capsules)
  2. Golden Teachers (found in all My Supply Co. capsules)
  3. African Transkei
  4. Penis Envy 6 (also available as capsules)
  5. Amazonian Cubensis
  6. Psilocybe Mexicana

We recommend the following magic mushroom strains for more gentle journeys:

  1. Brazilian Cubensis
  2. B+
  3. Cambodian Cubensis

How to use magic mushrooms for anxiety, depression, addiction, and TBI.

A collage art of a magic mushroom with people hanging off it, a concept of a ferris wheel. It describes microdosing and choosing a mushroom strain.

Given the profoundness of the subjective experience, it’s safe to assume that creating a setting conducive to your needs is the best way to use mushrooms therapeutically. It’s also currently the best way to tailor an experience to your needs rather than relying on strain choice.

For example, in one study, it was found that microdosing assisted in alleviating symptoms of depression. In the same study, researchers noted that it sometimes caused an acute increase in anxiety or a fluctuation in moods.

So if you’re taking magic mushrooms for anxiety, it might not be in your best interest to microdose — but to macrodose instead. The opposite may be true for depression.

In research on psychedelic therapy for addiction, participants typically showed an improvement in symptoms after a single session, suggesting that a macrodose may be most appropriate in this circumstance.

Below, we've listed the three most commonly studied and self-reported benefits of using psychedelics in a therapeutic setting. We also included a fourth bonus reason — performance enhancement (although this is not strictly therapeutic).

Remember: the advice you're about to read is not backed by clinical evidence, but the culmination of our coaching experience, the research mentioned above, and the contribution of thousands of magic mushrooms users that gave us enough anecdotal evidence to create testable hypotheses.

For anxiety…

If you’re using magic mushrooms for anxiety, you might want to macrodose. This involves taking a single, larger dose (1g or above) as a therapeutic session. This is not something you have to do regularly, although it might be (such as once every couple of months).

Read: The Ultimate Magic Mushroom Dosage Guide

It’s important to remember that macrodosing for therapeutic reasons should be void of any distractions.

It’s not a time to socialize or busy yourself with events. The experience should be in a quiet setting where you have the opportunity to immerse yourself in your mind and your therapy.

Read: How to Prepare for a Magic Mushroom Trip

To assist with any anxiety that may arise during the experience, it’s good to have a trip sitter or spiritual guidance (such as a shaman) observing you. This might also provide some comfort. 

For depression…

If you’re using magic mushrooms for depression, then there is some evidence to suggest that microdosing may be effective.

You can follow either the James Fadiman method or the Paul Stamets method, both of which are outlined in this guide to microdosing magic mushrooms.

It doesn’t mean you can’t use a macrodose every now and then to see whether or not that assists in long-term symptom relief. However, make sure to take at least a week between a macrodose and your next microdose to give your tolerance time to reset.

Again, as this is not backed up by science, it’s all a matter of subjective experience and effects.

Read:The Ultimate Guide to Magic Mushroom Microdosing

Read: Microdose Cycling: What It Is, and Why You Should Be Doing It

For addiction…

The most effective way of using magic mushrooms for addiction may be in the form of a macrodose. As with anxiety, this involves taking a single, larger dose in the context of a therapeutic session. 

Following the advice from earlier in this article, it’s pertinent to make an environment that is conducive to therapy during a macrodose. That means no social events, no social media — just time to meditate and focus on your therapy.

For traumatic brain injuries…

We’ve also published an article on how certain athletes have been using magic mushrooms to treat traumatic brain injuries such as CTE. These anecdotes report using sometimes just a single dose of magic mushrooms to bring on long-term effects. That might be all that’s required to see long term symptom relief, or it may need to be a therapy that’s topped up from time to time.

Involving your doctor or therapist.

A collage art depicting the concept of a shaman with a tiger, flowers, and an eye.

If you have a serious medical condition such as major depression, a brain injury, life-threatening addiction, or acute anxiety attacks, it’s important not to embark on therapy alone. If you choose to use magic mushrooms as an alternative therapy, it’s extremely important to involve your doctor or therapist — especially if you are taking other medications.

Not only does involving your therapist show your own independence in your healing process, but it also gives you someone to talk to about your revelations and process. Plus, you shouldn’t be diagnosing any conditions yourself or self-prescribing. It’s always important to get a professional’s opinion.

While there may not be a scientific rule book on how to choose a mushroom strain or which strains might be best for certain conditions, we can make certain hypotheses from where we’re standing. On top of this, the way you take magic mushrooms might be more pertinent than the kind of magic mushrooms you’re taking. 

Have you used magic mushrooms as therapy? What have you used them for and how did you use them? What kind did you use? We’d love to hear all about it in the comments!

Read: The Ultimate Guide to Magic Mushroom Microdosing

Read: The Ultimate Magic Mushroom Dosage Guide

Read: Microdose Cycling: What It Is, and Why You Should Be Doing It

Read: The Benefits of Microdosing Psilocybin — Without the Fluff

Read: How to Make Magic Mushroom Gummies

Read: How to Make Magic Mushroom Brownies

Read: How to Lemon Tek Magic Mushrooms

Read: How to Make Shroom Tea: The Ultimate Mushroom Tea Guide

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