Microdosing 101

The joy of being on point. How clarity, focus, and mental dexterity can help you excel at the things you care about.

What is microdosing?

It's taking sub-perceptual amounts of dried Psilocybin mushrooms to boost your energy, mood, focus, and sense of well-being. That means no visuals and no altered state of consciousness. This can range from 25mg to 300mg, depending on your tolerance, metabolism, and current brain chemistry.


We designed our microdose Stacks with 25mg Psilocybe cubensis per capsule to give you complete control over your microdose.

Should I microdose?

Microdosing is not a magic bullet. It is either a tool for enhancing your cognition, mood, and sense of well-being, or for restoring vital brain and body chemistry that is impaired by stress, depression, poor sleep, toxins, and oxidative stress. If you frequently exhibit the symptoms below, you may experience transformational shifts from microdosing:

  • brain fog
  • inability to concentrate
  • low or depressed mood
  • fatigue
  • irritability
  • cognitive impairment
  • digestive problems, including IBS
  • emotional sensitivity or mood swings
  • headaches
  • insomnia
  • low self-esteem

What can I expect from microdosing?

A sense of joyous energy, calm alertness, improved focus, and enhanced adaptability to stressors and challenges. After using our microdose Stacks, our customers report:

  • appreciating life more
  • being more calm and adaptable
  • decreased depression
  • decreased anxiety
  • increased creativity
  • a sense of peace or wellbeing


and more.

How do I microdose?

First, choose a microdosing protocol. The Fadiman and Stamets Protocols are the two most common, but we've compiled a full list here. Refer to this section's suggested reading for more tips on how to get started with microdosing.


You may need to experiment with a couple of protocols before landing on one that best supports your goals. Start with 25mg of dried Psilocybin mushrooms, and add another 25mg each microdosing day until it is no longer sub-perceptual. When that happens, dial it back by 1 capsule. Congratulations — you've found your ideal dose.

What is microdosing doing to my brain?

Microdosing Psilocybin is clinically studied to exert a number of benefits that support healthy cognitive aging. In addition to improvements in cognition and mood, microdosing also leads to improvements in gut health, energy balance, metabolism, and sleep quality:

  • Psilocybin has a high affinity for a specific type of serotonin receptor called 5-HT2AR. This receptor is essential for learning and cognition. It also plays an important role in your metabolism, gut health, immune function, sleep-wake cycle, and suppressing inflammation in the brain.
  • Psilocybin stimulates neurogenesis, the growth of new nerve cells from your own stem cells
  • Psilocybin enhances neuroplasticity, your nervous system’s ability to reorganize your nerve pathways
  • Psilocybin amplifies synaptoplasticity, making new synaptic connections by encouraging them to connect with nearby nerve cells


and more.

Formulations for transformation.

We created 3 advanced microdose formulas with unconventional superfood ingredients backed by innovative science for powerful results.


Packed with nootropic psilocybin, bioactive mushrooms, stress-busting adaptogens, and potent superfoods for proactive + reactive support, so you can unlock your true potential at every stage of your growth.

🔬 Clinically-studied to:


  • support healthy serotonin activity
  • promote calm alertness and concentration
  • promote mental stamina and clarity
  • improve learning and memory function
  • support speedy processing
  • reduce physical, mental, and emotional fatigue
  • boost energy and mood
  • protect from oxidative stress
  • control stress-related weight gain


and more.

Meet the Stacks.

Clean, nootropic microdose supplements designed to support vital brain and body chemistry to improve energy, mood, focus, and more.

🌱 Powered by Plants
🌏 Informed by Tradition
🧪 Backed by Science

✔️ Clinically-proven
✔️ Locally-grown organic mushrooms
✔️ 100% natural
✔️ Contaminant-free
✔️ Vegan
✔️ Non-GMO
✔️ 100% recyclable + reusable glass packaging

nuanced. fact-checked.

Check out our very full journal for the latest research and expert advice on magic mushrooms.

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Is it Safe to Mix Magic Mushrooms With Antidepressants?

Is it safe to mix magic mushrooms with antidepressants? We answer this common question in this article. Read here to learn more.

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How to Choose a Mushroom Strain & How to Use Them Therapeutically

The world of magic mushrooms has exploded — and not all of us know how to choose a mushroom strain. So we created this guide to help you out. Read more here.

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How to Make Shroom Tea: The Ultimate Mushroom Tea Guide

Our in-house psilocybin expert explains how to make tea out of shrooms in this guide to mushroom tea. Read on at My Supply Co.

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Magic Mushrooms and Penicillin Allergies: Is it Safe?

Magic mushrooms and penicillin allergies aren't very common, but does penicillin allergy make you more likely to be allergic to magic mushrooms? Find out here.

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The Ultimate Magic Mushroom Dosage Guide

From microdosing to megadosing to heroic dosing, we cover the different effects at every step of the way. Check out our ultimate guide to magic mushroom dosing.

Image of My Supply Co.'s Brain Stack for the Ultimate Guide to Magic Mushroom Microdosing

The Ultimate Guide to Magic Mushroom Microdosing

Check out this guide for Paul Stamets' and James Fadiman's microdosing protocols, along with some of the benefits of psilcoybin microdosing.

Read the MSC Journal