Full Spec. CBD Oil

Hi there! :-) Thank you so much for sharing your experience. We'd like to start by saying there aren't many human research on the combined effects of Naltrexone and cannabidiol (CBD), but here's what we do know: In a 2018 mouse study, researchers found that the combination of low doses of CBD plus naltrexone were more effective than either CBD or naltrexone alone at reducing ethanol consumption and the motivation to drink. The key takeaway: these effects appear to be mediated, at least in part, by 5‐HT1A serotonin receptors. Now, while these particular trials were conducted on mice, there are many human studies on the effects of CBD on 5-HT1A receptors. A 2020 study investigating CBD and 5-HT1A serotonin receptors concluded that, at low concentrations, the effect of CBD is limited. However, at high concentrations, CBD acts as an inverse agonist of 5-HT1A receptors. Inverse agonists could indirectly increase the signaling of targeted receptors through the increase in the proportion of receptors on the cellular surface. According to this information, the continuous administration of CBD as an inverse agonist of 5-HT1A receptors may represent a therapeutic strategy to augment the signaling of these and other Gi/o protein-coupled receptors involved in neuroprotection. Additional experiments are essential to support this notion. When it comes to long-term autoimmune healing, the data overwhelmingly supports the notion that CBD is immune suppressive and that the mechanisms involve direct suppression of activation of various immune cell types, induction of apoptosis, and promotion of regulatory cells, which, in turn, control other immune cell targets. This may be due to the endocannabinoid system (ECS), which plays a role in maintaining homeostasis, or balance, in the body. The ECS consists of endocannabinoid receptors, endocannabinoids, and enzymes. CBD increases endocannabinoid signalling by preventing the breakdown of endocannabinoids, which bind to endocannabinoid receptors to confer their therapeutic effects. Once the task is complete, and the endocannabinoids have served their purpose, enzymes break them down. Research suggests that endocannabinoids also control immune system functions. Additionally, the theory of clinical endocannabinoid deficiency proposed by Dr. Ethan Russo suggests that autoimmune conditions, among chronic health issues, may occur because a person lacks endocannabinoids. This is why cannabis or CBD may help with symptoms of these inflammatory disorders. We'd recommend starting with a regimen of 50mg Full Spec. CBD in the morning and 50mg Full Spec. CBD before bed. Drop it under your tongue, hold for at least 90 seconds, and swallow for the best results. Because it works on resetting your brain, establishing homeostasis, and has a range of molecular targets, it may take up to 90 days to start seeing results. Make sure you commit daily for at least a month. Remember—simple daily practices lead to transformational shifts. ��💙✨ We hope that helps! - My Supply Co. Team