CBD & THC Oils

There are two main differences between CBD oils, THC oils, and CBN oils:

1. Intoxicating effects: THC oils are intoxicatingly psychoactive, meaning that they affect your mood, perception, and other mental processes. They produce the “high” effects of cannabis. CBD oils and CBN oils are not intoxicating. They won’t get you high, but they can still have side effects, like making you feel relaxed or drowsy. CBN in particular is sedative and a powerful sleep aid.

2. Medical Benefits: CBD oils, THC oils, and CBN oils may have various health benefits, such as reducing pain, inflammation, anxiety, insomnia, seizures, and skin problems. However, the evidence for their effectiveness and safety is limited and varies depending on the condition and the individual. CBD oils have the most research support, especially for certain types of epilepsy. THC oils may help with conditions like nausea, appetite loss, and glaucoma. CBN oils may help with sleep and pain management.

There is no definitive answer to which oil is best for you, as it depends on your personal preferences, needs, and goals. You may want to consider the following factors when choosing an oil:

The effects you want: If you want to experience the intoxicating high of cannabis, you may prefer THC oil. If you want to avoid getting high, you may prefer CBD oil or CBN oil. If you want to feel relaxed or sleepy, you may prefer CBN oil, a combination of CBD oil and CBN oil, or a high CBD to THC ratio.

The benefits you need: THC is best for improving mood, sleeping better, and reducing chronic pain, inflammation, nausea, and cancer cell growth. CBD is daily support for reducing stress, anxiety, depression and a href="https://mysupplyco.com/journal/cannabis-for-mood-scientific-review/">improving mood and focus, and CBN is best for improving sleep quality.

CBD regulates the stress response by interacting with the endocannabinoid system (ECS), a network of receptors and molecules that modulate various physiological processes, including mood, pain, and inflammation. The ECS is involved in maintaining homeostasis, or balance, in the body and brain.

When the body is exposed to stress, the ECS can become dysregulated, leading to increased levels of cortisol, the stress hormone, and reduced levels of endocannabinoids, the natural compounds that bind to ECS receptors.

CBD may help restore the balance of the ECS by enhancing the levels and activity of endocannabinoids, such as anandamide and 2-AG, and by binding to other receptors, such as serotonin and vanilloid, that are involved in stress regulation. By doing so, CBD may reduce the negative effects of stress on the brain and body, such as anxiety, depression, inflammation, and oxidative damage.

In seven double-blind placebo-controlled clinical studies on CBD for stress, CBD significantly reduced stress and its manifestations (anxiety, depression, burnout, fear), and was non-inferior to pharmaceuticals like SSRIs and benzodiazepines.

CBD promotes healthy inflammation and balances the inflammatory response by modulating your immune system and suppressing the production of pro-inflammatory cytokines, which are molecules that trigger inflammation.

CBD also activates the PPAR-gamma receptor, which is involved in regulating inflammation and metabolism. By activating this receptor, CBD may inhibit the activation of NF-kB, a transcription factor that controls the expression of many inflammatory genes.

Additionally, CBD enhances the anti-inflammatory effects of endocannabinoids, such as anandamide, by preventing their breakdown by the enzyme FAAH. CBD also interacts with other receptors, such as TRPV1 and GPR55, that are implicated in inflammation and pain.

CBD reduces anxiety by influencing several neurotransmitter systems in the brain that are involved in emotional regulation, such as serotonin, glutamate, and GABA.

CBD acts as a partial agonist of the 5-HT1A receptor, a subtype of serotonin receptor that mediates anxiety and mood. By activating this receptor, CBD may increase the availability of serotonin, a neurotransmitter that has antidepressant and anxiolytic effects.

CBD may also modulate the activity of glutamate and GABA, two neurotransmitters that balance excitatory and inhibitory signals in the brain. CBD may enhance the function of GABA, an inhibitory neurotransmitter that reduces anxiety and stress, and inhibit the function of glutamate, an excitatory neurotransmitter that can cause overstimulation and anxiety.

Furthermore, CBD may reduce anxiety by stimulating the endocannabinoid system, which regulates the stress response and plays a role in fear extinction and memory consolidation.

CBD may reduce depression by affecting several mechanisms that are implicated in the pathophysiology of depression, such as neuroinflammation, neurogenesis, synaptic plasticity, and neuroendocrine function.

CBD's anti-inflammatory properties can counteract the chronic inflammation that is associated with depression and neurodegeneration.

CBD also promotes neurogenesis, the formation of new neurons, in the hippocampus, a brain region that is involved in memory, mood regulation, and cognitive function.

CBD may enhance synaptic plasticity, the ability of synapses to change and adapt, by increasing the levels of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal survival and growth.

CBD may also modulate the neuroendocrine system, which regulates the secretion of hormones that affect mood, stress, and sleep. CBD can lowers the levels of cortisol (the stress hormone) and increase the levels of melatonin (the sleep hormone), both of which are frequently disrupted in depression, to improve mood and circadian rhythms.

CBD may improve sleep quality by addressing some of the underlying causes of sleep disturbances, such as an exaggerated stress response, anxiety, pain, and inflammation.

If you have chronic stress or anxiety, CBD is clinically proven to reduce stress and its manifestations (anxiety, depression, burnout, fear) and relax the mind and body, helping you fall asleep faster and improving sleep quality and duration.

CBD also has analgesic and anti-inflammatory effects that can alleviate certain chronic pain conditions and discomfort that can interfere with sleep quality and duration.

CBD also interacts with two systems that play central roles in regulating your sleep: The Endocannabinoid System (ECS), which regulates your sleep-wake cycle, and your nervous system, where it influences the levels and activity of melatonin, serotonin, and adenosine, which are molecules that control the circadian rhythms and sleep pressure. CBD increases melatonin, the sleep hormone, by activating the 5-HT1A serotonin receptor, which is involved in melatonin synthesis, and increases adenosine levels, a neurotransmitter that accumulates during wakefulness and gradually increases sleepiness.

CBD improves mood by affecting several neurotransmitter systems that are involved in mood regulation, such as serotonin, dopamine, and endocannabinoid.

CBD may act as a partial agonist of the serotonin receptor 5-HT1A, which mediates mood and emotion. By activating this receptor, CBD may increase the availability of serotonin, a neurotransmitter that has antidepressant and mood-enhancing effects.

CBD also modulates the activity of dopamine, a neurotransmitter that regulates motivation, reward, and pleasure. CBD increases the levels of dopamine in the prefrontal cortex, a brain region that is involved in executive functions and mood control, by inhibiting the enzyme that breaks down dopamine.

CBD also stimulates the endocannabinoid system, which plays a central role in mood regulation and emotional processing. CBD enhances the levels and activity of endocannabinoids, such as anandamide and 2-AG, which have mood-elevating and stress-reducing effects.

CBD improves focus by increasing blood flow to the prefrontal cortex, the area of the brain responsible for executive functions, such as decision-making, planning, and problem-solving. Improved blood flow leads to better cognitive performance, reduced distractions, and increased concentration and productivity.

CBD also improves focus by reducing anxiety and stress, which can impair attention and cognitive function. CBD reduces anxiety and stress by activating serotonin and vanilloid receptors that are involved in stress and pain modulation. It also reduces anxiety and stress by stimulating the endocannabinoid system, which regulates the stress response and plays a role in fear extinction and memory consolidation.

CBD also improves focus by enhancing neurogenesis and synaptic plasticity, the formation of new neurons and synapses, in the hippocampus, a brain region that is involved in learning and memory. CBD enhances neurogenesis and synaptic plasticity by increasing the levels of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal survival and growth.

CBD's neuroprotective benefits are underpinned by its ability to protect our brain networks and promote neuroplasticity, the ability of the brain to change and adapt. It does so by influencing several mechanisms that are involved in neuronal development, survival, and function.

CBD may promote neuroplasticity by enhancing neurogenesis, the formation of new neurons, in the hippocampus, a brain region that is involved in learning and memory. CBD may enhance neurogenesis by activating the cannabinoid receptor CB1, which stimulates the proliferation and differentiation of neural stem cells.

CBD also promotes neuroplasticity by increasing the levels of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal survival and growth. CBD increase the levels of BDNF by activating the serotonin receptor 5-HT1A, which is involved in BDNF synthesis.

CBD also promotes neuroplasticity by modulating synaptic transmission, the communication between neurons, by influencing the activity of glutamate and GABA, two neurotransmitters that balance excitatory and inhibitory signals in the brain. It enhances synaptic transmission by inhibiting the reuptake and degradation of glutamate and GABA, increasing their availability and efficacy.

CBD may improve cognitive function by affecting several mechanisms that are involved in cognition, such as memory, attention, and executive functions.

CBD improves cognitive function by enhancing neurogenesis and synaptic plasticity, or the formation of new neurons and synapses, in the hippocampus, a brain region that is involved in learning and memory. it does so by activating the cannabinoid receptor CB1, which stimulates the proliferation and differentiation of neural stem cells, and by increasing the levels of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal survival and growth.

CBD also improves cognitive function by increasing blood flow to the prefrontal cortex, the area of the brain responsible for executive functions, such as decision-making, planning, and problem-solving. Improved blood flow leads to better cognitive performance, reduced distractions, and increased concentration and productivity.

CBD also improves cognitive function by reducing inflammation and oxidative stress, which can impair neuronal function and cause neurodegeneration. It reduces inflammation and oxidative stress by activating the PPAR-gamma receptor, which is involved in regulating inflammation and metabolism, by acting as an antioxidant, which scavenges free radicals and protects neurons from damage, and by boosting our natural antioxidant defenses, your body's innate ability to maintain balance between pro- and anti-oxidants.

CBD also improves cognitive function by modulating the activity of various neurotransmitter systems that are involved in cognition, mood, and motor function, such as serotonin, dopamine, and glutamate. By activating the 5-HT1A serotonin receptor, CBD increases the availability of serotonin, a neurotransmitter that has antidepressant and cognitive-enhancing effects. CBD may also modulate the activity of dopamine, a neurotransmitter that regulates motivation, reward, and pleasure. CBD may increase the levels of dopamine in the prefrontal cortex, a brain region that is involved in executive functions and cognitive control, by inhibiting the enzyme that breaks down dopamine. CBD may also modulate the activity of glutamate, an excitatory neurotransmitter that is involved in learning and memory. CBD may enhance the function of glutamate by inhibiting its reuptake and degradation, increasing its availability and efficacy.

CBD may decrease addiction by interfering with the reward and reinforcement mechanisms that underlie substance use disorders.

CBD may reduce the rewarding and reinforcing effects of addictive substances, such as opioids, nicotine, and alcohol, by blocking or modulating the activity of cannabinoid, opioid, and dopamine receptors in the brain.

CBD may also reduce the craving and withdrawal symptoms that are associated with addiction, such as anxiety, irritability, and insomnia, by activating serotonin and vanilloid receptors that are involved in stress and pain modulation.

CBD may also facilitate the extinction and prevention of drug-seeking behavior, by enhancing the function of the endocannabinoid system, which is involved in learning and memory processes.

CBD isolate is a single-compound extract that contains pure CBD, devoid of any other cannabinoids, terpenes, flavonoids, or other compounds that are naturally present in the cannabis plant. On the other hand, full-spectrum CBD contains CBD along with other cannabinoids, terpenes, flavonoids, and other compounds that are naturally present in the cannabis plant. These compounds may have different effects on the human body and mind, depending on their source, potency, and dosage.

CBD isolate has some advantages, such as:

• It has a higher concentration of CBD per unit of weight, which may make it more potent and effective for some conditions and individuals.
• It has no flavor or odor, which may make it more palatable and easier to use in different forms and methods.
• It has less risk of interacting with other medications or supplements, as it has fewer compounds that may trigger them.
• It has no THC, which means it won’t show up on drug tests (this is less relevant now that it is legal in Canada).

CBD isolate may have some disadvantages, such as:

• It does not provide the full range of benefits that CBD can offer, as it lacks the other cannabinoids, terpenes, flavonoids, and other compounds that have synergistic or complementary effects with CBD. This is known as the entourage effect, which suggests that the whole plant is more effective than its isolated components.
• Studies demonstrate that CBD isolate only works at around 300mg per dose to achieve the same effects as full-spectrum CBD, as it may have lower bioavailability and efficacy.
• It is well-tolerated and safe, but studies show that it is more likely to cause side effects like nausea and upset stomach than full-spectrum CBD.

Full-spectrum CBD may have some advantages, such as:

• It provides the full range of benefits that CBD can offer, as it contains the other cannabinoids, terpenes, flavonoids, and other compounds that have complementary effects with CBD. This enhances the therapeutic potential and diversity of CBD for different conditions and individuals.
• It requires a lower dose to achieve the same effects as CBD isolate as it is more effective than CBD isolate.
• It has a linear dose-response, meaning the more you take, the more benefits you experience. Note that higher doses may cause drowsiness.

Full-spectrum CBD may have some disadvantages, such as:

• It contains trace amounts of THC (under 0.3%), which is unlikely to cause intoxication but may show up on drug tests.
• It may have a distinct flavor or odor, which may make it less palatable and harder to use in different forms and methods.

CBD isolate and full-spectrum CBD may interact with other medications or supplements differently, as they have different profiles of cannabinoids and other compounds that can influence the metabolism and efficacy of other substances.

CBD isolate and full-spectrum CBD may both interact with some medications or supplements, such as blood thinners, antidepressants, and anticonvulsants, by inhibiting the activity of cytochrome P450 (CYP450), a family of enzymes that are responsible for breaking down and eliminating many drugs and supplements from the body. This may increase the levels and effects of these substances, which may lead to unwanted or harmful consequences.

CBD isolate and full-spectrum CBD may also interact with some medications or supplements, such as opioids, benzodiazepines, and alcohol, by enhancing or reducing their effects, depending on the dose and the type of cannabinoid or other compound involved. This may result in increased or decreased sedation, euphoria, or pain relief, which may also have negative or dangerous outcomes.

You should consult your doctor before using either if you are taking any medications, especially if you are taking high doses or have a serious medical condition. You should also monitor your response and adjust your dosage accordingly.

There are many different types of THC oils, from Rick Simpson Oil (RSO) to distillates. We aqre specifically referring to tinctures, liquid extracts of cannabis that are taken sublingually (under the tongue) for quick absorption. Tinctures are versatile, and can also be added to food or beverages, although this makes them less bioavailable and reduces their effects.

THC oils differ from other cannabis consumption methods like edibles, smoking, or vapes because of their liquid form, higher bioavailability, and faster onset of effects.

THC tinctures are often used for medical purposes, such as pain relief, anxiety management, and promoting sleep. In more chronic settings, they're used to relieve fibromyalgia pain, reduce Parkinson's pain and tremors, and promote cancer cell growth and reduce cancer-related pain and depression. However, it's important to consult with a healthcare professional before using THC products for medical reasons to ensure they align with your specific health needs.

Consider factors such as your desired goals and outcomes. If you're looking for more energetic and creative experiences, try Uplift. Uplift is THC oil infused with organic cannabis-derived terpenes that are known for their energizing, sunny, bright, and focus-enhancing effects. If you're looking for a THC oil that is relaxing and soothing, like a hug from your favourite sweater, consider Unwind. This THC oil is infused with terpenes known for their calm and tranquil properties.

For gentle and potent pain relief, or for enhancing recovery from an active lifestyle, we recommend picking a THC oil that is also rich in CBD. We have two oils with distinct CBD to THC ratios to feed your need—1 CBD : 1 THC Oil and 3 CBD : 1 THC Oil.

Not sure which Ratio is right for you? Check out our Quick Guide to Finding Your Ideal CBD-to-THC Ratio.

The best way to use CBN Sleep Solution is by dropping it under your tongue and holding it there for about a minute before swallowing. This allows the CBN and other clinical-grade actives to enter your bloodstream quickly and efficiently.

Alternatively, you can add CBN Sleep Solution to beverages, such as making your own spiced cannabis milk. However, this method may reduce the bioavailability and effectiveness of CBN, as it has to pass through your digestive system first.

There is no definitive answer to how much CBN oil you should take, as the optimal dosage may vary depending on your body weight, metabolism, tolerance, and desired effects. However, a general rule of thumb is to start low and go slow.

Begin with a small dose, such as 2.5 to 5 milligrams of CBN, and observe how you feel. If you do not experience any adverse effects, you can gradually increase your dose until you find the amount that works best for you.

CBN oil may have several benefits, based on preliminary research and anecdotal evidence. Some of the potential benefits of CBN oil are:

• Pain relief: CBN oil may help reduce pain by interacting with the endocannabinoid system, which regulates pain perception and inflammation. A 2019 study1 found that CBN relieved pain in rats. It concluded that CBN might be able to soothe pain in people with conditions like fibromyalgia.
• Sleep aid: CBN oil may help improve sleep quality and duration by inducing relaxation and sedation. A 1975 study2 suggested that CBN has a mild sedative effect when combined with THC. However, more research is needed to confirm the efficacy and safety of CBN oil for sleep.
• Appetite stimulant: CBN oil may help increase appetite and food intake by activating the CB1 receptors in the brain, which are involved in appetite regulation. A 2012 study3 showed that CBN made rats eat more food for a longer period of time. This could be beneficial for people who suffer from appetite loss due to various causes, such as cancer or HIV.
• Anti-inflammatory: CBN oil may help reduce inflammation and swelling by modulating the immune system and inhibiting the production of pro-inflammatory cytokines. A 2016 study4 found that CBN reduced inflammation and joint damage in a mouse model of arthritis.
• Antibacterial: CBN oil may help fight bacterial infections by disrupting the cell membranes of bacteria and preventing them from multiplying. A 2008 study demonstrated that CBN had antibacterial activity against several strains of drug-resistant bacteria, such as MRSA.

CBN oil is generally considered to be safe and well-tolerated, but it may cause some mild side effects in some people. Some of the possible side effects of CBN oil are:

• Drowsiness: CBN oil may cause drowsiness, especially when taken in high doses or combined with other sedatives, such as alcohol or antihistamines. This may impair your ability to drive, operate machinery, or perform other tasks that require alertness. Therefore, it is advisable to avoid using CBN oil before or during these activities.
• Dry mouth: CBN oil may cause dry mouth, also known as cottonmouth, by reducing the production of saliva in your mouth. This may lead to thirst, bad breath, or difficulty swallowing. To prevent or relieve dry mouth, you can drink plenty of water, chew sugar-free gum, or use a mouth spray.
• Low blood pressure: CBN oil may cause low blood pressure, also known as hypotension, by dilating your blood vessels and reducing your heart rate. This may result in dizziness, lightheadedness, or fainting. If you have low blood pressure or take medications that lower your blood pressure, you should use CBN oil with caution and monitor your blood pressure regularly.
• Drug interactions: CBN oil may interact with some medications, such as blood thinners, antidepressants, or anticonvulsants, by affecting their metabolism or efficacy. This may increase the risk of bleeding, serotonin syndrome, or seizures. If you take any medications, you should consult your doctor before using CBN oil and avoid mixing it with other substances.

Both CBD (cannabidiol) and THC (tetrahydrocannabinol) have potential pain-relieving properties, but they work in different ways. CBD is known for its anti-inflammatory and analgesic effects without producing a psychoactive "high." THC, on the other hand, directly interacts with pain receptors in the brain. The choice between CBD and THC for pain depends on personal preferences and sensitivity to psychoactive effects. Some individuals find relief with CBD alone, but most will benefit from a combination of CBD and THC.

For a practical, expert-written guide for choosing the right cannabinoid to manage your pain, our guide THC vs. CBD for Pain: Which is Better, and For What? covers the pain types and conditions that CBD and THC are best suited for according to clinical studies.

The combination of CBD and THC is known as the entourage effect, the theory that the synergistic interaction between these cannabinoids enhances their therapeutic effects. For example, the presence of THC may enhance the pain-relieving properties of CBD and vice versa.

While CBD is clinically studied to work better with THC, and vice versa, it's essential to consider your tolerance and preferences. Always start with low doses when combining CBD and THC to gauge your body's response.

It's difficult to give a definitive answer since research is limited. While endocannabinoids, molecules naturally produced by the body that are similar to CBD and THC, are present in breast milk, the potential impact of phytocannabinoids on infant development remains unclear.

Although CBD has shown little risk for adults and children, you should decide whether taking CBD oils while breastfeeding is right for you after weighing its benefits, such as addressing postpartum issues, against the unknown effects on the infant's endocannabinoid system. While some mothers opt for CBD as an alternative to traditional treatments, like antidepressants and anti-anxiety meds, Health Canada emphasizes caution and consultation with a healthcare professional.

Studies show that people that consume cannabis have more fulfilling sex lives. CBD can help ease you into the mood by reducing stress, pain, and anxiety. THC can help get the juices flowing by increasing sensitivity, reducing pain and inflammation, and elevating your mood. However, consuming THC on a frequent and daily basis may result in erectile dysfunction in men, or adversely impact female fertility. Learn how to properly use cannabis for sex here.

We recommend taking up to 150mg of CBD oil, two times daily. However, there is no one-size-fits-all when it comes to CBD dosage—it comes down to your unique chemistry, and your health goals.

Our CBD Dosage Calculator is designed to help you find your ideal dose based off of your weight and your goals. Just pick from a list of dozens of conditions and benefits (e.g. anxiety, sleep, pain relief, arthritis, endometriosis), enter your weight, and it will provide you with a daily CBD dosage and protocol. You can also read our CBD dosage guide for more helpful tips on finding your ideal introductory dose.