Psilocybin (Magic Mushroom) Capsules

Frequently Asked Questions

What are magic mushroom capsules?

Magic mushroom capsules are a convenient form of ingesting a precise dose of ground magic mushrooms. Each capsule contains a measured amount of psilocybin, the primary psychoactive compound in magic mushrooms. This method offers a discreet and controlled way to experience the effects.

How do magic mushrooms work in the brain?

The effects of magic mushrooms, specifically psilocybin, are attributed to its interaction with various neurotransmitter systems in the brain. Here's a breakdown:


  • Default Mode Network (DMN): Psilocybin, once ingested, affects the Default Mode Network (DMN) of the brain. The DMN is a network of interconnected regions associated with self-referential thoughts, mind-wandering, and the sense of ego. Psilocybin seems to dampen the activity of the DMN, leading to a reduction in the sense of self and increased connectivity between brain regions that don't typically communicate.
  • Serotonin Receptors: Psilocybin is structurally similar to serotonin, a neurotransmitter that plays a crucial role in mood regulation. Psilocin, the active form of psilocybin, binds to serotonin receptors, particularly the 5-HT2A receptor. This interaction is thought to contribute to the psychedelic effects and alterations in mood, perception, and cognition.
  • Glutamate Release: Psilocybin also influences the release of glutamate, an excitatory neurotransmitter. The modulation of glutamate levels is associated with changes in synaptic plasticity, contributing to the altered perception and sensory experiences reported during a psychedelic trip.
  • Brain-Derived Neurotrophic Factor (BDNF): There is evidence suggesting that psilocybin may increase the levels of Brain-Derived Neurotrophic Factor (BDNF). BDNF is a protein that supports the growth, maintenance, and survival of neurons. Higher levels of BDNF are associated with neuroplasticity, the brain's ability to adapt and reorganize itself, which is implicated in learning, memory, and mood regulation.
  • Neurogenesis: Some studies suggest that psilocybin may stimulate neurogenesis, the formation of new neurons. This is a fascinating area of research as it implies that magic mushrooms might have the potential to promote brain regeneration.

The combined effects on the DMN, serotonin receptors, glutamate release, BDNF levels, and potential neurogenesis contribute to the reported therapeutic benefits of magic mushrooms. Individuals often describe a sense of interconnectedness, improved mood, and increased creativity. It's important to note that research in this area is ongoing, and while these mechanisms provide insights, the full scope of psilocybin's impact on the brain is still not fully understood. As with any substance, it's crucial to approach its use with respect, caution, and awareness of individual differences.

What are the primary psychoactives in magic mushrooms?

The primary psychoactive compounds in magic mushrooms are psilocybin, its metabolite psilocin, and baeocystin. Psilocin mimics serotonin, influencing mood and perception. It's unknown what the exact role of baeocystin is, but it's understood that it interacts with psilocin in an important way.

what are psilocybin microdose capsules?

My Supply Co. psilocybin microdose capsules provide small, precisely-controlled doses of magic mushrooms. Microdoses typically range between 25mg (0.025 grams) and 300mg (0.3 grams). As such, My Supply Co.'s psilocybin microdose capsules deliver 25mg of dried raw mushrooms, while our macrodose capsules deliver 250mg of dried raw mushrooms.


Users report benefits such as increased creativity, focus, and mood enhancement without the full psychedelic experience.

Which psilocybin microdose capsules should I take for anxiety/depression/ADHD?

If you have both anxiety and depression, we recommend Brain Stack, while for just depression we recommend Vitality Stack. For ADHD, we recommend Energy Stack.


Individuals dealing with anxiety and depression often find relief with our Brain Stack, a formulation combining Psilocybin Mushrooms with Lion's Mane, Sage, Vitamin B3, and Cinnamon. Lion's Mane enhances cognition, mood, is neuroprotective, while Sage and Cinnamon promote calm, clarity, and mental stamina. This combination works synergistically to alleviate symptoms of anxiety and depression.


if you're specifically seeking relief from depression, Vitality Stack can be an effective alternative. Inflammation, oxidative stress, and depression have a reciprocal relationship. When one increases, so does the other two. Vitality Stack, formulated with Psilocybin Mushrooms, Chaga, Cordyceps, Turmeric, Cinnamon, and Vitamin B3, targets depression at the source by combating oxidative stress, inflammation, and boosting cellular energy and immune function. You'll also feel happy when your skin and hair start looking healthier. ;-)


On the other hand, Energy Stack is ideal for those dealing with ADHD. The blend of Psilocybin Mushrooms, Cordyceps, Matcha, Vitamin B3, Cinnamon, and Peppermint is designed to not only provide an immediate jitter-free energy boost but also enhance focus and brain function. Psilocybin, Cordyceps, and Matcha, in particular, are known for their potential in improving cognitive performance and brain function, making them valuable ingredients for ADHD.

What's the difference between your microdose capsules?

Our microdose capsules, Brain Stack, Energy Stack, and Vitality Stack, offer distinct benefits tailored to specific needs.


  • Brain Stack emphasizes cognitive function, mood enhancement, and calmness. It optimizes focus, memory, and clarity, making it an excellent choice for individuals seeking mental acuity and emotional balance.
  • Energy Stack goes beyond a traditional energy supplement, supporting immediate energy needs while enhancing cellular energy, metabolism, and overall brain function. It's a comprehensive choice for sustained energy, improved mood, and cognitive performance.
  • Vitality Stack, designed to combat oxidative stress and inflammation, acts as a youth elixir. Combining Psilocybin Mushrooms with Chaga, Cordyceps, Turmeric, Cinnamon, and Vitamin B3, it boosts cellular energy and immune function, promoting a sense of vitality and resilience.

Each formulation incorporates a unique blend of ingredients to address specific aspects of well-being. The choice between Brain Stack, Energy Stack, or Vitality Stack depends on individual preferences and goals, allowing you to tailor your microdosing experience to your desired outcomes.

Can I combine microdose capsules from different formulas?

Yes, our microdose capsules are designed to be taken together for synergistic effects. Combining capsules strategically can enhance your overall microdosing experience. Here are ways you can optimize their intake:


  • Comprehensive Microdosing: Consider taking capsules from different formulas on the same microdosing day to experience a broad range of benefits. For example, combining Brain Stack for cognitive enhancement, Energy Stack for sustained energy, and Vitality Stack for cellular health can provide a holistic microdosing experience.
  • Rotational Microdosing: Rotate between different formulations on different days to target specific aspects of well-being. This approach allows you to focus on cognitive function, energy, or vitality on specific days, promoting a balanced and varied microdosing routine.
  • Tailored Combinations: Customize your microdosing routine based on your individual needs and preferences. For instance, combining Brain Stack with Energy Stack can provide both cognitive enhancement and sustained energy for days requiring peak performance.

Optimal Dosage:

Each of our microdose capsules contains 25mg of psilocybin mushrooms. To optimize intake:


  • Start Low and Adjust: Begin with a low total dosage, especially if you're new to microdosing or combining formulas. Observe how your body responds and adjust the dosage gradually based on your sensitivity and desired effects.
  • Consistent Schedule: Establish a consistent microdosing schedule. While individual preferences may vary, a common schedule is every third day to maintain a steady level of psilocybin in your system.

What are psilocybin macrodose capsules?

My Supply Co. psilocybin macrodose capsules provide larger precisely-controlled doses of magic mushrooms. They're typically used by those seeking the profound insights, spiritual experiences, and therapeutic effects that come with full psychedelic experiences. We also also recommend them for museums, music events, artistic endeavors, and those searching for deeper and out-of-the-ordinary ways to share connection, belly laughs, and good times with friends and loved ones.

What's the difference between your macrodose capsules?

Our macrodose capsules, Balanced High (a.k.a. Scooby Snacks) and Extended Release (a.k.a. Increased Time Under Curve), offer different macrodosing experiences.


  • Balanced High (Scooby Snacks) provides a shorter and more uplifting journey. It's designed for those who seek an energizing and positive macrodose experience without an extended duration.
  • Extended Release (Increased Time Under Curve) delivers a longer and gentler macrodose journey. This formulation is ideal for individuals who prefer a more prolonged and gradual experience.

Each formulation incorporates unique herbal ingredients to create distinctive macrodosing effects, allowing users to choose based on their preferences and desired experience.

Can I combine macrodose capsules from different formulas?

Yes, our formulas are designed to be taken together for synergistic effects, so you can tailor the trip to your preference.

Can psilocybin help with PTSD?

Emerging research suggests that psilocybin, the active compound in magic mushrooms, may have therapeutic potential for PTSD. Psilocybin interacts with serotonin receptors, particularly the 5-HT2A receptor. By modulating serotonin activity and influencing the Default Mode Network (DMN), psilocybin may contribute to reduced avoidance behavior and enhanced emotional processing, potentially offering relief to individuals struggling with PTSD symptoms.

Can psilocybin help with anxiety?

Psilocybin may have anxiolytic effects, potentially alleviating anxiety symptoms. This is believed to occur through the modulation of serotonin receptors, particularly the 5-HT2A receptor, and the resulting changes in brain connectivity in the Default Mode Network (DMN). Psilocybin's impact on the amygdala, a brain region associated with fear and anxiety, may contribute to a temporary reduction in anxiety levels.

Can psilocybin help with depression?

Psilocybin's impact on depression is thought to be linked to its ability to modulate serotonin receptors and increase levels of Brain-Derived Neurotrophic Factor (BDNF). The resetting effect on the Default Mode Network (DMN) is also associated with a reduction in depressive thought patterns. These combined effects may contribute to the alleviation of depressive symptoms and an improved overall mood.

Can psilocybin help with ADHD?

While research on psilocybin and ADHD is limited, some studies suggest that the compound's influence on serotonin receptors and glutamate release could potentially impact attention and focus. Psilocybin's modulation of brain networks might contribute to improved cognitive flexibility. However, it's crucial to note that more research is needed to fully understand the implications of psilocybin for ADHD, and you should approach its use cautiously and under professional guidance.

What is psilocybin therapy, and can I use these magic mushroom capsules during psilocybin therapy?

Yes. The psilocybin therapist you work with will likely allow you to source the material yourself since they are not allowed to do so for you.

Psilocybin therapy is a type of psychedelic therapy that specifically utilizes the magic of psilocybin mushrooms.


Not all psychedelic therapists in Canada will facilitate the actual journey for you. In those cases, they will provide you with tips and tools to prepare for your magic mushroom journey. They will also help you process and integrate your insights and experiences post-journey.


Despite their scarcity, there are psychedelic therapists in Canada that are willing to work with patients through the journey itself, although they may not publicly advertise this service. During a psilocybin therapy session, you ingest a carefully measured dose of psilocybin in a comfortable setting conducive to introspection and self-reflection. The trained facilitator or therapist provides guidance and support throughout the experience, helping you navigate your thoughts, emotions, and any challenging aspects that may arise.


Psilocybin therapy is often utilized for various mental health conditions, including depression, anxiety, PTSD, and existential distress. The psychedelic experience induced by psilocybin is believed to allow individuals to explore and address deep-seated issues, gain insights, and experience a shift in perspective.


The therapeutic benefits of psilocybin are thought to arise from its interaction with serotonin receptors, particularly the 5-HT2A receptor, as well as its influence on brain networks such as the Default Mode Network (DMN). This may lead to profound experiences, increased self-awareness, and a temporary alteration of perception, facilitating therapeutic breakthroughs.


It's crucial to note that psilocybin therapy is a specialized form of treatment and should only be conducted by trained professionals in a legal and controlled setting. The aim is to harness the potential therapeutic effects of psilocybin in a supportive context, allowing individuals to explore their psyche and promote positive psychological changes. As research in this field continues, psilocybin therapy represents a promising area for mental health treatment, but its use should be approached with caution and responsibility. Always consult with qualified healthcare professionals before considering psilocybin therapy.

What are the strongest strains used in magic mushroom capsules?

Psilocybe azurescens and Penis Envy (from the Psilocybe cubensis species) are just 2 variants known for their potency. Starting with lower doses is advised, given the strength of these strains. Learn more about these strains in our guide to the 10 most potent mushroom strains.

What are the most common strains used in magic mushroom capsules?

Some of the most common magic mushroom strains include Psilocybe cubensis variants like Golden Teacher and B+, which can largely be attributed to 3 things: they're easy to grow, they have gentle, balanced, yet potent effects, and they offer consistent and predictable psilocybin concentrations. Effects vary but often include altered sensory perception, mood enhancement, and introspective experiences. Learn more about these strains and more in our guide to 20 must-know magic mushroom strains.

How can magic mushrooms be used therapeutically?

Therapeutic use involves careful use of magic mushrooms, including proper preparation, intention-setting, and integration.


We recommend trying microdosing for depression, and macrodosing for anxiety. However, both approaches can work for a variety of mental health concerns, depending on your commitment to the practice and growth.

Are there any potential risks or side effects?

While many users report positive experiences, potential risks include "bad trips"/anxiety, nausea, and in rare cases, hallucinogen persisting perception disorder (HPPD). It's crucial to be informed, start with a low dose, and consider individual health conditions. Consultation with a healthcare professional is advised, especially if you're on medications or have pre-existing conditions.

Is it safe to mix magic mushrooms with antidepressants?

Studies show that it is likely safe to . Learn more about the known interactions between psilocybin and medications in our guide to mushrooms and prescription meds, including antidepressants, antipsychotics, and more.

Can you lemon tek with magic mushroom capsules?

Lemon tekking is a method of enhancing the effects of magic mushrooms by soaking them in citrus juice, primarily lemon, to increase the bioavailability and absorption of magic mushrooms, resulting in a quicker onset, reduced nausea, and a more intense psychedelic experience. While not recommended for microdosing, lemon tekking is possible and encouraged to enhance your experience with our macrodose capsules, Balanced High and Extended Release.


How to lemon tek magic mushrooms with our capsules:


  • Step 1:Open the desired number of capsules for your intended dose. A common starting point is one-third of your usual dose, as Lemon Tek can increase potency significantly.
  • Step 2:Place the contents of the capsules in a small cup or glass.
  • Step 3:Squeeze fresh lemon or citrus juice into the cup, ensuring the contents are fully covered. Use enough juice to immerse the capsule contents thoroughly.
  • Step 4:Let the mixture sit for approximately 20 minutes. During this time, the lemon juice will start to break down the mushroom material, potentially leading to a quicker onset and more intense experience.
  • Step 5:After 20 minutes, stir the mixture and consume it promptly. The effects may come on more rapidly than traditional ingestion methods.

Caution and Dosage:


Lemon tekking can intensify the effects of magic mushrooms, sometimes by 2-5 times. Exercise caution, especially if you're new to psychedelic experiences. Starting with one-third of your usual dose is advisable to account for the potentiation effect of lemon tek.

Read our guide to lemon tekking for a step-by-step explanation of the process, plus tips and tricks you haven't read anywhere else. Alternatively, learn how to make mushroom tea.