Key takeaways.
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How does lion’s mane stimulate the brain and the gut?
Lion’s mane stimulates the brain and the gut through the 5-HT2A receptor, which is involved in mood, anxiety, cognition, and memory. This helps to improve your emotional processing, openness, and fear extinction (the process of reducing or eliminating your fear response to something). Because 5-HT2A is the same serotonin receptor that psilocybin mushrooms stimulate, we suggest combining the two to optimize your brain and gut chemistry. You can find both in Brain Stack, our all-in-one nootropic formula.
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How does lion’s mane effect the gut microbiota and its functions?
Lion’s mane acts as both a prebiotic and a probiotic. This helps to improve the digestion, absorption, and production of nutrients, while also protecting the gut lining and regulating inflammation and appetite.
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How does lion’s mane improve the communication and coordination between the brain and the gut?
Lion’s mane improves the communication and coordination between the brain and the gut by stimulating the vagus nerve, which connects the brain and the gut. This may help maintain the balance and harmony of the gut-brain axis, which is essential for mental and physical health.
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How can lion’s mane be used safely and effectively for gut health?
Lion’s mane can be used safely and effectively for gut health by consuming it in various forms, such as fresh or dried mushrooms, powder, or extracts. Brain Stack, our master nootropic formula, combines neuroprotective lion's mane with psilocybin mushrooms and other powerful herbs and superfoods to provide multi-depth support to your gut-brain axis. However, it is important to use caution and moderation, as lion’s mane may have side effects or interactions with some medications, and may also have psychoactive effects.
Lion’s mane (Hericium erinaceus) can do wonders for our mental health and is known for its mood, cognition, and brain health benefits. but what about our ‘second brain’—the gut? Gut health is essential for the health of your whole body, and research shows that lion’s mane can maintain digestive health, and even alleviate symptoms of digestive issues.
Learn how Lion’s Mane can support your brain-gut axis by improving digestion, supporting healthy gut function, reducing inflammation, and balacing your gut microbiome—and see how My Supply Co.'s Brain Stack can fit into your daily routine.
What is the gut-brain axis?
The gut-brain axis is the two-way communication system between your gastrointestinal tract and the central nervous system. It involves neural, hormonal, and immune pathways, and is heavily influenced by gut microbiota, the diverse community of microorganisms that inhabit the gut.
Gut microbiota can change the way that we produce and metabolize neurotransmitters like serotonin, dopamine, and gamma-aminobutyric acid (GABA), which are involved in mood, cognition, and behavior. Gut microbiota can also affect the immune system, the inflammatory response, and the stress response, which are linked to various mental health conditions.
How lion’s mane affects the gut-brain axis.
Lion’s mane contains bioactive compounds that can stimulate the growth of nerve cells and protect them from damage. These bioactive compounds include hericenones and erinacines, which can activate the serotonin 2A (5-HT2A) receptor, a subtype of serotonin receptor that is widely distributed in the brain and the gut.
Interestingly, while the 2A serotonin receptor is responsible for the hallucinogenic effects of classic psychedelics, it also plays a role in regulating mood, anxiety, cognition, and memory. By stimulating the 5-HT2A receptor, lion’s mane may enhance the emotional processing of positive and negative stimuli, increase the openness to new experiences, and reduce or eliminate your fearful response to triggers. These effects underlie the therapeutic potential of lion’s mane for mental health disorders, such as depression, anxiety, and post-traumatic stress disorder (PTSD).
However, while both lion's mane and psilocybin target the 2A serotonin receptor, lion's mane promotes NGF (nerve growth factor), whereas psilocybin promotes BDNF (brain-derived neurotrophic factor). Because they have overlapping but unique properties, we recommend stacking lion's mane with psilocybin for a healthy and happy brain.
Lion’s mane also has a positive effect on other neurotransmitter systems, such as dopamine, glutamate, and acetylcholine, which are involved in reward, learning, memory, and attention. By influencing these systems, lion’s mane may improve cognitive function, motivation, and creativity.
We've said a lot about how lion's brain benefits the brain. But how does it benefit the gut?
There's significant evidence suggesting that your state of mind influences the state of your gut. Chronic stress, depression, and anxiety are frequently coupled with dysfunction of the gut, such as Crohn's, IBS, or IBD. That's because these conditions are usually accompanied by high levels of inflammation and neurotransmitter imbalances.
Lion’s mane may indirectly affect the gut through the brain, which influences gut motility, secretion, sensation, intestinal permeability, and inflammation through the vagus nerve, the main nerve that connects the brain and the gut. The vagus nerve can also transmit signals from the gut to the brain, informing the brain about the state of the gut and its microbiota. Therefore, lion’s mane may help improve the communication and coordination between the brain and the gut, which is essential for maintaining mental and physical health.
How lion’s mane affects gut microbiota.
Your gut microbiota is the collection of microorganisms that live in your gut. It consists of bacteria, fungi, viruses, and other microbes that have various functions and interactions. Gut microbiota can help digest food, produce vitamins and short-chain fatty acids, compete with pathogens, and interact with the immune system. Gut microbiota can also affect the brain, as mentioned above, by producing and metabolizing neurotransmitters and influencing the vagus nerve.
The composition and function of your gut microbiota can be influenced by many factors, such as diet, lifestyle, genetics, medications, and environmental exposures. Dysbiosis, or the imbalance of the gut microbiota, can lead to various health problems, such as obesity, diabetes, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), allergies, and autoimmune diseases.
Lion's Mane: Prebiotic and Probiotic?
As a prebiotic, lion's mane provides fiber in the form of beta-glucan, food your gut microbiome thrives on for its roles in maintaining immune function, antioxidant defenses, and overall digestive health.
Because lion’s mane is prebiotic, meaning that it can serve as food for the beneficial bacteria in the gut, it may help restore the balance and diversity of your gut microbiota.
As a probiotic, lion's mane Lion’s mane also has probiotic effects, meaning that it can introduce or enhance the growth of beneficial bacteria in the gut. For example, lion’s mane may increase the abundance of Bifidobacterium and Lactobacillus, two genera of bacteria that are associated with improved gut health and immunity. Lion’s mane may also reduce the abundance of Helicobacter pylori, a bacterium that can cause stomach ulcers and gastric cancer.
By modulating your gut microbiota, lion’s mane may improve the digestion and absorption of nutrients, as well as the production of short-chain fatty acids, which are important for the health of your gut lining and regulating inflammation and appetite. Lion’s mane may also protect the gut from oxidative stress and inflammation, which can damage the gut lining and increase the risk of leaky gut syndrome, a condition where the gut becomes more permeable and allows toxins and bacteria to enter the bloodstream, triggering systemic inflammation and immune reactions.
How to use lion's mane for gut health.
Lion's Mane mushroom is a delight to the senses in its taste and powerful effects. Even if you are lucky enough to find it fresh in the grocery store, you still don't know how many active compounds, like beta-glucans and polysaccharides, the mushroom contains.
If you're looking to get the benefits of Lion's Mane, you need a way to standardize your amount. Standardized extracts are the best way to go, as they tell you exactly how many ingredients you want in your supplement.
One of the easiest ways to add this functional mushroom to your daily routine is with Brain Stack, our all-in-one nootropic formula. It's also sugar-free, gluten-free, vegan, non-GMO, and easy to digest.
This adaptogenic microdose formula not only puts lion's mane's benefits within reach for anyone, but it also combines the brain-boosting and gut-boosting benefits of other clinically-proven nootropics and vitamins. Ingredients like Psilocybin mushrooms, Spanish sage, and vitamin b3. Each capsule provides 250mg of a patented extraction of certified organic Lion's Mane fruiting bodies, standardized to >25% 1,3 and 1,6 beta-glucans.
Lion’s mane is available in various forms, such as fresh or dried mushrooms, powder, capsules, tablets, tinctures, or extracts. The dosage and preparation of lion’s mane may vary depending on the product and the purpose of use. However, some general guidelines are:
- As part of a specialized formula: Brain Stack combines lion's mane with psilocybin mushrooms, vitamin b3, cinnamon, and sage to optimize brain chemistry, functional connectivity, and combat neuroinflammation.
- Fresh or dried mushrooms: Lion’s mane mushrooms can be eaten raw, cooked, or added to soups, salads, or other dishes. The recommended dosage is about 10-20 grams per day, or about one or two mushrooms.
- Powder: Lion’s mane powder can be mixed with water, juice, smoothies, coffee, tea, or other beverages. The recommended dosage is about 1-3 grams per day, or about one or two teaspoons.
- Capsules, tablets, or extracts: Lion’s mane capsules, tablets, or extracts can be taken with water or other liquids. The recommended dosage may vary depending on the product and the concentration of the active compounds, but it is usually about 500-1000 mg per day, or about one or two capsules, tablets, or droppers.
Lion’s mane is generally considered safe and well-tolerated, but some people may experience mild side effects, such as nausea, diarrhea, or allergic reactions. Lion’s mane may also interact with some medications, such as anticoagulants, antidepressants, or antipsychotics, so it is advisable to consult your doctor before taking lion’s mane if you are on any medication. Lion’s mane may also have psychoactive effects, such as enhancing mood, creativity, and perception, so it is advisable to use caution and moderation when taking lion’s mane, especially if you are sensitive to psychedelics or have a history of mental health issues.
Potential side effects of lion's mane.
Lion’s mane is generally considered safe and well-tolerated, but some people may experience mild side effects or adverse reactions, usually related to allergic sensitivity. They include:
- Difficulty breathing
- Skin rashes
- Nausea Diarrhea
- Abdominal discomfort
These side effects may be more likely to occur in people who are allergic to mushrooms or other fungi, or who take high doses or certain formulations of lion’s mane supplements. To avoid or minimize these side effects, it is advisable to start with a low dose and gradually increase it, or take lion’s mane with food or water. If you experience any severe or persistent side effects, stop taking lion’s mane and consult your doctor
Lion's mane's potential medical interactions.
Lion’s mane may interact with certain medications that affect blood clotting, blood sugar, or mood. Therefore, it is advisable to consult your doctor before taking lion’s mane if you are on any medication or supplement. Some possible interactions or precautions include:
Lion's Mane, Anticoagulants, and Antiplatelet Drugs
Lion’s mane may slow blood clotting and increase the risk of bleeding if taken with these drugs, such as warfarin, aspirin, or clopidogrel. Monitor your bleeding and clotting time closely.
Lion's Mane and Diabetes Medications
Lion’s mane may lower blood sugar levels and cause hypoglycemia if taken with these medications, such as insulin, metformin, or sulfonylureas. Monitor your blood sugar levels closely.
Lion's Mane, Antidepressants, and Antipsychotics
Lion’s mane may enhance or interfere with the effects of these medications, such as fluoxetine, sertraline, or risperidone, by affecting the serotonin 2A receptor and other neurotransmitter systems. Monitor your mood and mental state closely.
Lion's Mane, Sedatives, and Anxiolytics
Lion’s mane may have psychoactive effects, such as enhancing mood, creativity, and perception, and may result in enhanced sedative effects if taken with medications such as diazepam, lorazepam, or alprazolam. Use caution and moderation when taking lion’s mane, especially if you are sensitive to psychedelics or have a history of mental health issues.
Should you be taking lion's mane for gut health?
Lion’s mane is a mushroom that has been used for centuries for its medicinal and culinary properties. It has been shown to have beneficial effects on brain health, but it can also support gut health by improving the gut-brain axis and the gut microbiota.
Lion’s mane may help improve digestive function, reduce inflammation, and balance the gut ecosystem, which may lead to improved overall health and well-being.
Lion’s mane can be consumed in various forms, such as fresh or dried mushrooms, powder, capsules, tablets, or extracts, but it is important to use caution and moderation, as lion’s mane may have side effects or interactions with some medications. If you are interested in trying lion’s mane for brain function, gut health, and sleep, you can find more information and products from the following sources:
Discover: Brain Stack | Microdose Capsules
Read: How This Mushroom Magnifies Memory, Mood, and Mental Dexterity
Read: Lion’s Mane Before Bed: How This Mushroom Supports Sound Sleep
Read: 3 Incredible Lion’s Mane Benefits for Your Brain, Gut, and Sleep
Read: Top Nootropics That Help You Sleep Better
Lion's mane for gut health FAQs:
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What is the best time of day to take lion’s mane?
There is no definitive answer to the best time of day to take lion’s mane, as it may depend on your personal preference, schedule, and goals. However, some general guidelines are:
▸ If you want to take lion’s mane for cognitive enhancement, you may want to take it in the morning or before a mentally demanding task, as it may boost your focus, alertness, and creativity.
▸ If you want to take lion’s mane for mood support, you may want to take it in the afternoon or evening, as it may help you relax, reduce stress, and improve your sleep quality.
▸ If you want to take lion’s mane for gut health, you may want to take it with or after a meal, as it may improve your digestion, absorption, and production of nutrients.However, these are not strict rules, and you may experiment with different timings to find what works best for you. The most important thing is to take lion’s mane consistently and regularly to enjoy its benefits.
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How does lion’s mane affect the brain?
Lion’s mane contains compounds that can stimulate the growth and repair of brain cells, such as hericenones and erinacines. These compounds can activate the serotonin 2A receptor, which is involved in mood, anxiety, cognition, and memory. Lion’s mane may also modulate other neurotransmitter systems, such as dopamine, glutamate, and acetylcholine, which are involved in reward, learning, memory, and attention. By affecting these systems, lion’s mane may improve cognitive function, motivation, and creativity.
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What are the benefits of lion’s mane for gut health?
Lion’s mane may help restore the balance and diversity of the gut microbiota, as it has prebiotic and probiotic effects. Lion’s mane may also protect the gut from oxidative stress and inflammation, which can damage the gut lining and increase the risk of leaky gut syndrome. By modulating the gut microbiota, lion’s mane may improve the digestion and absorption of nutrients, as well as the production of short-chain fatty acids, which are important for the health of the gut lining and the regulation of inflammation and appetite.
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How long does it take to see the effects of lion’s mane?
The effects of lion’s mane may vary depending on the individual, the dosage, the form, and the purpose of use. Some people may notice improvements in their mood, memory, or focus within a few days or weeks of taking lion’s mane, while others may need longer periods of time to see the benefits. For neurological health and nerve regeneration, lion’s mane may take several months to show its effects, as nerve growth and repair is a slow process. For optimal results, lion’s mane should be taken consistently and regularly, as its effects may wear off if the intake is stopped.
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Can lion’s mane interact with other medications or supplements?
Lion’s mane is generally considered safe and well-tolerated, but it may interact with some medications or supplements that affect blood clotting, blood sugar, or mood. For example, lion’s mane may increase the risk of bleeding if taken with anticoagulants or antiplatelet drugs, such as warfarin, aspirin, or clopidogrel. Lion’s mane may also lower blood sugar levels if taken with diabetes medications, such as insulin, metformin, or sulfonylureas. Lion’s mane may also enhance or interfere with the effects of antidepressants or antipsychotics, such as fluoxetine, sertraline, or risperidone. Therefore, it is advisable to consult your doctor before taking lion’s mane if you are on any medication or supplement
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Can lion’s mane cause upset stomach?
Lion’s mane is generally well-tolerated, but some people may experience mild gastrointestinal discomfort, such as nausea, diarrhea, or bloating, after consuming it. This could be due to individual sensitivities, dosage, or the specific formulation of the supplement. To avoid or minimize these side effects, it is advisable to start with a low dose and gradually increase it, or take lion’s mane with food or water.
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Does lion’s mane make you gain weight?
Lion’s mane is unlikely to make you gain weight, as it is low in calories and high in fiber, which can help you feel full and reduce your appetite. On the contrary, lion’s mane may help you lose weight or prevent weight gain by improving your metabolism, reducing inflammation, and modulating your gut microbiota. Animal studies have shown that lion’s mane can reduce weight gain, lower triglyceride levels, and improve insulin sensitivity in mice fed a high-fat diet. However, more human studies are needed to determine the effects of lion’s mane on weight management and obesity.
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Can you take lion’s mane on an empty stomach?
You can take lion’s mane on an empty stomach or with food, depending on your personal preference and desired benefits. Some people claim that taking lion’s mane on an empty stomach can increase absorption, speed the effects, and reduce GI upset. However, others may experience stomach discomfort or nausea when taking lion’s mane without food, especially in high doses or in supplement form. Taking lion’s mane with food can also improve absorption and digestion, especially if taken with a meal that contains healthy fats, as the active compounds in lion’s mane are fat-soluble. However, taking lion’s mane with food high in fiber may interfere with absorption, as the fiber can bind to the active compounds and prevent them from entering the bloodstream. Therefore, it is important to experiment and find the best method for your individual needs, considering the potential benefits and side effects of each approach
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