Frequently Asked Questions
Brain Stack is our master nootropic microdose supplement for proactive and reactive brain health, formulated to optimize cognitive function by enhancing focus, memory, and mental clarity across several major neurological systems. It supports the production of key neurotransmitters, BDNF, and other pathways crucial for optimal brain function and long-term brain health.
Brain Stack microdose capsules are formulated to support long-term cognitive health by focusing on three key aspects:
- Supports neuron synaptic formation: Neuron synaptic formation is essential for the development and maintenance of connections between neurons. These connections facilitate communication within the brain, which is crucial for learning, memory, and cognitive function. Brain Stack supports this process, helping to maintain and improve cognitive abilities over time.
- Supports acetylcholine signaling: Acetylcholine is a neurotransmitter that plays a significant role in memory, learning, and attention. It is involved in various cognitive processes and is crucial for maintaining optimal brain function. Brain Stack supports acetylcholine signaling, thereby contributing to better cognitive performance and overall brain health.
- Supports brain mitochondrial function: Mitochondria are the powerhouse of cells, producing the energy required for cellular activities. Healthy brain mitochondrial function is vital for maintaining cognitive abilities and preventing age-related decline in brain function. Brain Stack supports brain mitochondrial function, ensuring that your brain receives the energy it needs to perform optimally.
By addressing these key areas and more, Brain Stack promotes long-term cognitive health, making it especially important for individuals wanting to optimize memory and brain health throughout the aging process.
Stress, depression, toxins, and oxidative stress deplete vital brain chemistry and prematurely shrink your brain, leading to brain fog, poor memory, irritability, anxiety, and more. Brain Stack, a brain supplement, is our master nootropic microdose formula that's clinically shown to help restore vital brain chemistry and functional brain connectivity and promote memory, concentration, mood, and brain vitality.
Brain Stack microdose capsules have Psilocybin, Lion's Mane, Cinnamon, Sage, and Vitamin B3 to create an intelligent neurotransmitter recycling system. Psilocybin and Lion's Mane modulate monoamine neurotransmitters like serotonin, dopamine, and norepinephrine to help wake the mind and mood, improve your ability to adapt to stress, and enhance BDNF (brain-derived neurotrophic factor) production. BDNF in turn promotes the survival and differentiation of serotonin and dopamine neurons so they're able to continue supporting vital brain chemistry and enhance functional brain connectivity.
Vitamin B3 helps convert fat, carbs, and protein into cellular energy/ATP while supporting healthy serotonin production.
Cinnamon and Sage deliver a potent antioxidant complex to protect the brain from inflammation and oxidative stress.
Brain Stack promotes neuroplasticity through its carefully selected ingredients, which work synergistically to support the brain's ability to adapt, change, and form new connections.
Here's how the ingredients in Brain Stack contribute to neuroplasticity:
- Organic Psilocybe Cubensis: This ingredient has been studied for its potential to promote neurogenesis (the formation of new neurons) and synaptogenesis (the formation of new synapses). It activates serotonin receptors responsible for mood and memory consolidation, fostering an environment for improved brain connectivity and plasticity.
- Organic Lion's Mane: Lion's Mane is known for its neuroprotective properties and its ability to improve cognition. It increases the release of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), which are key molecules involved in plastic changes related to learning and memory. By increasing the levels of these growth factors, Lion's Mane supports neuroplasticity and overall brain health.
- Organic Sage: Sage is rich in terpenes and phenolics, which have been shown to improve memory and attention. These compounds can help to create an environment in the brain that is conducive to neuroplasticity, supporting the brain's ability to adapt and change.
- Organic Cinnamon: Cinnamon has been shown to reduce oxidation and inflammation in the brain, which can be detrimental to neuroplasticity. By protecting the brain from oxidative stress and inflammation, cinnamon helps to create a healthier environment for neuroplastic changes to occur.
By combining these ingredients, Brain Stack effectively promotes neuroplasticity, helping to support and optimize cognitive function, memory, and overall brain health.
Brain Stack promotes neurogenesis, the process of generating new neurons in the brain, through its unique combination of ingredients. Each ingredient plays a role in creating an environment that supports and stimulates the growth of new neurons, contributing to improved cognitive function and brain health.
Here's how the ingredients in Brain Stack promote neurogenesis:
- Organic Psilocybe Cubensis: Research suggests that Psilocybe Cubensis may have neuroprotective properties and can stimulate the growth of new neurons in the brain. It activates serotonin receptors responsible for mood and memory consolidation, which may contribute to an environment that supports neurogenesis.
- Organic Lion's Mane: Lion's Mane is known for its ability to improve cognition and promote neurogenesis. It increases the release of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), which are essential proteins for the growth, maintenance, and survival of neurons. By increasing the levels of these growth factors, Lion's Mane supports the generation of new neurons and overall brain health.
- Organic Sage: Sage contains compounds like terpenes and phenolics that have been shown to improve memory and attention. These compounds may help create an environment in the brain that is conducive to neurogenesis, supporting the growth of new neurons.
- Organic Cinnamon: Cinnamon has been shown to reduce oxidation and inflammation in the brain, which can negatively impact neurogenesis. By protecting the brain from oxidative stress and inflammation, cinnamon helps create a healthier environment for the growth of new neurons.
By incorporating these ingredients, Brain Stack effectively promotes neurogenesis, optimizing cognitive function, memory, and overall brain health.
BDNF and serotonin are seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. An imbalance of one typically results in an imbalance of the other, leading to anxiety, depression, and other mood disorders.
In pre-clinical trials, Lion's Mane completely reversed stress- and depression-induced low levels of norepinephrine, dopamine, serotonin, and BDNF in the hippocampus.
Psilocybin is shown to have a similar effect on serotonin, dopamine, and BDNF in the pre-frontal cortex (PFC).
Together, Psilocybin and Lion's Mane in Brain Stack support healthy neurotransmitter signaling and BDNF expression in both the PFC and Hippocampus — improving memory, promoting focus, and enhancing your ability to adapt to and overcome stress.
The ingredients in Brain Stack's microdose capsules work by targeting several key aspects of brain function and promoting long-term cognitive health through its carefully selected ingredients. Here's a detailed breakdown of how Brain Stack works:
- Enhances BDNF (brain-derived neurotrophic factor): BDNF is a protein that supports the survival, growth, and maintenance of neurons. It plays a vital role in learning, memory, and overall brain health. Brain Stack enhances BDNF production, promoting neuroplasticity and cognitive function.
- Supports neuron and synaptic function: Neurons are the basic building blocks of the brain, and synapses are the connections between them. Brain Stack supports healthy neuron and synaptic function, enabling efficient communication within the brain and ultimately leading to improved cognitive abilities.
- Supports prefrontal cortex and hippocampus activity: The prefrontal cortex is involved in executive functions such as decision-making, planning, and attention, while the hippocampus plays a critical role in memory formation and consolidation. Brain Stack supports the activity of these brain regions, contributing to enhanced cognitive performance.
- Supports neurotransmitter signaling: Neurotransmitters are chemical messengers that transmit signals between neurons, playing a crucial role in various cognitive processes. Brain Stack supports neurotransmitter signaling, particularly acetylcholine and serotonin 5-HT2A, which are essential for memory, learning, and attention.
- Enhances stress resilience: Stress can negatively impact cognitive function and overall brain health. Brain Stack helps to enhance the brain's resilience to stress, protecting cognitive abilities and promoting mental well-being.
By targeting these key areas, Brain Stack effectively supports and optimizes brain function, leading to improvements in focus, memory, mental clarity, and overall cognitive performance.
Brain Stack contains various ingredients that help manage stress through different mechanisms, such as promoting relaxation, reducing cortisol levels, and enhancing the brain's resilience to stress.
Studies show that stress and depression can cause imbalances in neurotransmitters and BDNF (brain-derived neurotrophic factors), leading to structural changes in functional connectivity and causing your brain to shrink. Brain Stack combats the effects of stress at the source by restoring vital brain chemistry and functional connectivity to support calm alertness, lightning-fast processing, memory, mood, and mental adaptability.
When the stress response activates, all 5 ingredients help to nourish and protect the brain. Then Sage comes in to help the brain cope with stress and reduce irritability. As stress continues, energy gets depleted. Vitamin B3 helps convert fat, carbs, and protein into energy. Prolonged periods of stress, poor sleep, and diet can impact functional brain connectivity. Psilocybin brings clarity and enhances memory by improving functional brain connectivity, while Lion's Mane is studied to be neuroprotective. Cinnamon promotes healthy blood flow to the brain to reduce irritability and protects it from oxidative stress.
- Organic Psilocybe Cubensis: Psilocybe Cubensis has been shown to help modulate the HPA axis, which is responsible for the body's stress response (Carhart-Harris et al., 2017). By doing so, it can reduce cortisol levels and improve the brain's ability to cope with stress. Additionally, Psilocybe Cubensis may enhance global functional brain connectivity, which can contribute to better stress management (Carhart-Harris et al., 2017).
- Organic Lion's Mane: Lion's Mane may help protect the brain from damage caused by chronic stress through its anti-inflammatory and antioxidant properties (Li et al., 2017). Additionally, Lion's Mane has been shown to improve sleep quality and mood, which can contribute to better stress management.
- Organic Sage: Sage has antioxidant, anti-inflammatory, and neuroprotective properties, which can help manage stress by reducing inflammation and oxidative stress in the brain (Rezvanfar et al., 2018). Furthermore, sage has been shown to improve mood, cognition, and memory, which can contribute to better stress management.
- Organic Cinnamon: Cinnamon has been shown to have anti-inflammatory and antioxidant properties, which can help protect the brain from the negative effects of stress (Rao et al., 2009). In addition, cinnamon can help improve memory, increase attention, and enhance cognitive processing, which can contribute to better stress management.
Yes. Brain Stack contains ingredients that have been shown to help reduce anxiety by promoting relaxation, improving mood, and enhancing cognitive function.
These ingredients include:
Organic Psilocybe Cubensis: Psilocybe Cubensis can help alleviate anxiety by activating serotonin receptors, which play a crucial role in mood regulation and overall well-being (Carhart-Harris et al., 2017). In addition, Psilocybe Cubensis may improve global functional brain connectivity, which can contribute to better anxiety management (Carhart-Harris et al., 2017).
Organic Lion's Mane: Lion's Mane has been shown to have anti-inflammatory and antioxidant properties, which can help protect the brain from damage caused by chronic stress and anxiety (Li et al., 2017). Moreover, Lion's Mane may enhance sleep quality and mood, which can contribute to better anxiety management.
Organic Sage: Sage has antioxidant, anti-inflammatory, and neuroprotective properties, which can help manage anxiety by reducing inflammation and oxidative stress in the brain (Rezvanfar et al., 2018). Furthermore, sage has been shown to improve mood, increase alertness, and promote calmness, which can help reduce anxiety.
Organic Cinnamon: Cinnamon has been shown to have anti-inflammatory and antioxidant properties, which can help protect the brain from the negative effects of anxiety (Rao et al., 2009). In addition, cinnamon can help improve memory, increase attention, and enhance cognitive processing, which can contribute to better anxiety management.
Brain Stack contains ingredients that can help improve attention and cognitive processing, which are often challenges for individuals with ADHD.
These ingredients include:
- Organic Psilocybe Cubensis: Research suggests that Psilocybe Cubensis may help improve attention and cognitive processing by activating serotonin receptors, which can regulate mood and overall cognitive function (Carhart-Harris et al., 2017). Furthermore, Psilocybe Cubensis may improve global functional brain connectivity, which can contribute to better ADHD management (Carhart-Harris et al., 2017).
- Organic Lion's Mane: Lion's Mane has been studied for its potential to improve cognition and support brain health, which can be beneficial for individuals with ADHD (Li et al., 2017). By increasing the release of NGF and BDNF, Lion's Mane can enhance synaptic plasticity and neural communication, leading to better focus and attention. Additionally, Lion's Mane has been shown to enhance sleep quality and mood, which can contribute to better ADHD management.
- Organic Sage: Sage contains compounds that have been shown to improve memory and attention, which can help manage ADHD symptoms (Rezvanfar et al., 2018). Furthermore, sage has been shown to improve mood and cognitive function, which can contribute to better focus and concentration in individuals with ADHD.
- Organic Cinnamon: Cinnamon has been shown to improve memory and increase attention, which can be helpful for individuals with ADHD (Rao et al., 2009). In addition, cinnamon's anti-inflammatory and antioxidant properties may help support brain health and overall cognitive function.
Brain Stack contains ingredients that help alleviate depression through various mechanisms, such as improving mood, increasing the release of growth factors that support brain health, and reducing inflammation. These ingredients include:
These ingredients include:
Organic Psilocybe Cubensis: Psilocybe Cubensis may help alleviate depression by activating serotonin receptors, which play a crucial role in mood regulation and overall well-being (Carhart-Harris et al., 2017). In addition, Psilocybe Cubensis may improve global functional brain connectivity, which can contribute to better depression management (Carhart-Harris et al., 2017).
Organic Lion's Mane: Lion's Mane may help reduce depression by increasing the release of NGF and BDNF, which support brain health and resilience (Li et al., 2017). These growth factors can help improve synaptic plasticity and neural communication, leading to better cognitive function and a more balanced mood. Moreover, Lion's Mane has been shown to enhance sleep quality and mood, which can contribute to better depression management.
Organic Sage: Sage has antioxidant, anti-inflammatory, and neuroprotective properties, which can help manage depression by reducing inflammation and oxidative stress in the brain (Rezvanfar et al., 2018). Furthermore, sage has been shown to improve mood, increase alertness, and promote calmness, which can help reduce depression.
Organic Cinnamon: Cinnamon has been shown to have anti-inflammatory and antioxidant properties, which can help protect the brain from the negative effects of depression (Rao et al., 2009). In addition, cinnamon can help improve memory, increase attention, and enhance cognitive processing, which can contribute to better depression management.
Psilocybe Cubensis promotes neurogenesis and synaptogenesis, and improves global functional brain connectivity. Lion's Mane is neuroprotective and improves cognition, sleep quality, and mood. Sage improves memory, attention, mood, and alertness. Cinnamon reduces oxidation and inflammation in the brain while improving memory and cognitive processing. Niacin addresses Vitamin B3 deficiencies essential for cognition, energy production, and cellular protection.
No, Brain Stack as a product is not clinically tested. The ingredients themselves have been clinically tested through the monumental effort of scientists and specialists around the world.
We formulated Brain Stack based on their demonstrated benefits and effects to create a master nootropic supplement for complete proactive + reactive brain health.
Yes! All of our Stacks are vegan and tested for pesticides, heavy metals, microbiological content, and more.
Energy Stack, Brain Stack, and Vitality Stack microdose capsules are all designed to enhance specific aspects of your overall health and well-being. While they are all nootropic microdose capsules and there may be some overlapping benefits, each supplement focuses on a distinct area of your health and well-being.
Energy Stack is a microdose supplement primarily targets both cognitive and physical performance, with a particular emphasis on supporting the brain's energy demands. This supplement is formulated to provide clean, lasting energy, enhance mental and athletic performance, boost memory and productivity, and improve libido and fertility in men and women.
Brain Stack is a microdose supplement that is specifically designed for proactive and reactive brain health, aiming to enhance focus, memory, and mental clarity across several major neurological systems. This supplement supports your body's ability to produce key neurotransmitters and optimize brain function, fueling focus, productivity, mental energy, and reducing anxiety while improving sleep quality.
Vitality Stack is a comprehensive microdose supplement focusing on cellular health, hormonal balance, and overall vitality. This supplement is crafted to combat stress, support cognitive function, and protect against accelerated aging caused by stress and oxidative damage. It aims to provide a whole-body rejuvenation by targeting cellular health, promoting healthy aging, and enhancing overall well-being.
So, which is right for you?
Energy Stack is best for those looking to improve cognitive and physical performance, Brain Stack is ideal for those seeking enhanced brain health and mental clarity, and Vitality Stack is designed for individuals wanting to improve overall vitality, cellular health, and combat the effects of stress and aging.
They all have 25mg Psilocybe cubensis per capsule, and confer the mind and mood-optimizing benefits of Psilocybin.
Yes, in fact, we recommend it. All of our products are formulated in doses designed to be taken together. We recommend taking them in the AM.
+ Brain Stack is proactive + reactive brain health for mood, memory, and concentration
+ Energy Stack is your non-stim wakeup call for boosting energy, metabolism, and mood
+ Immune Stack is restorative cellular care for your brain, sex, hair, skin, recovery, and immune goals
While some users may experience immediate results, the full benefits of Vitality Stack are typically seen after consistent use over a period of 4 weeks or more.
Follow the Paul Stamets protocol by taking 1–4 caps together for 4 consecutive days, then 3 days without a microdose. Repeat for 4–8 weeks, followed by a 2–4 week break. This completes on microdose cycle.
"Brain Stack" is designed for cognitive clarity, emotional regulation, and consistent performance. Unlike one-size-fits-all stacks, it combines psilocybin mushrooms, Lion’s Mane, Vitamin B3 (as Niacin), and other natural nootropics in synergistic doses optimized for microdosing.
No. Brain Stack contains a sub-perceptual dose of psilocybin, designed to enhance baseline function without inducing a psychedelic trip. You may feel more focused, present, creative, or emotionally balanced — but not "high."
Morning or early afternoon is ideal. Psilocybin and Vitamin B3 (as Niacin) are stimulating for some users, and taking Brain Stack too late in the day might interfere with sleep.
Most people report less anxiety, brain fog, and fatigue and improved focus, clarity, productivity, mood regulation, creativity, and self-awareness within the first few weeks. Benefits often build subtly over time — like becoming a better version of yourself
Some notice shifts on the first dose — like better focus, reduced anxiety, or a lighter mood. For most, the full benefits emerge gradually over 2–6 weeks of consistent microdosing.
Brain Stack contains psilocybin mushrooms (Golden Teacher strain) — known for their balance of clarity, compassion, and cognitive stimulation — plus Lion’s Mane and Vitamin B3 (Niacin) to support enhance neurogenesis and delivery.
Niacin (vitamin B3) acts as a delivery enhancer, increasing circulation and helping the active compounds in Brain Stack reach your brain and nervous system more effectively. It also contributes to natural energy production, enhancing metabolism by helping your body convert fat, carbs, and protein into ATP/cellular energy.
Lion’s Mane is a medicinal mushroom that enhances dopamine signaling, serotonin activity, and supports nerve growth factor (NGF) production, which aids in neuroplasticity, focus, memory, and brain repair over time — especially in synergy with psilocybin.
Yes — Brain Stack's nootropic formula is specifically designed for first-time microdosers as well as experts. The dose is low, reliable, and easy to integrate into daily life.
Yes. Many users pair Brain Stack with coffee or adaptogens. However, we suggest avoiding high-stimulation stacks at first to tune into how Brain Stack feels on its own.
You might feel stronger sensory enhancement, emotion, or introspection. It's not dangerous — but you may want to stay home and rest.
Store Brain Stack in a cool, dark, dry place, away from heat and sunlight. Refrigeration is optional but can help extend freshness.
We recommend journaling your energy, focus, mood, memory, and productivity each day. Over time, subtle improvements often become visible in patterns you didn’t expect.
Brain Stack works best when taken with intention, curiosity, and self-awareness. Set a simple goal — whether it's clarity, patience, or presence — and reflect on how your day unfolds.
100% Natural 
100% Plant-Sourced 
100% Recyclable 
Contaminant Free 
Cruelty-Free 
Gluten-Free 
Keto-Friendly 
Locally Grown Organic Mushrooms 
No Additives 
No Preservatives 
Non-GMO 
Nut-Free 
Sugar-Free 
Vegan 
