The science behind Lion's Manes proactive + reactive brain-boosting benefits, explained.

Key Takeaways:

What are neurotrophic factors?

Proteins synthesized by the body that are critical for learning and memory. They create new brain cells that are more open, flexible, and communicative.

What affects my production of neurotrophic factors?

Your brain naturally generates them during exercise and other healthy, pleasurable activities that activate your serotonin 5-HT2A receptors, but stress and aging lead to a decrease in neurotrophic factors.

Does Lion's Mane help?

Lion's Mane, a nootropic adaptogenic mushroom, is studied to promote the synthesis of NGF and BDNF, two key neurotrophic factors.

Have you heard of neurotrophic factors?

Neurotrophic factors like Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factors (BDNF) are key molecules involved in plastic changes related to learning and memory.

In other words, they strengthen brain connections, aiding learning and memory. Think of them as gardeners in your brain. They plant, nurture, and cultivate strong neural connections, like roots, that allow information to flourish and bloom throughout your brain's garden.


How This Mushroom Magnifies Memory, Mood, and Mental Dexterity | Wellness | My Supply Co.

Well, neurotrophic factors are absolutely essential for the creation, growth, and survival of new neurons, or brain/nerve cells. That's because they're known to invigorate nerve cells in three ways:

  1. They stimulate neurogenesis, the growth of new nerve cells from your own stem cells.
  2. They enhance neuroplasticity, your nervous system’s ability to reorganize your nerve pathways.
  3. They amplify synaptoplasticity, making new synaptic interconnections between neurons by encouraging them to grow new tendrils that reach out and make new connections with nearby nerve cells.

So, NGF and BDNF give you new brain cells that are more open, flexible, and communicative.

They allow you to create new pools of brain cells, then create new healthy connections in the parts of your brain that control your memory and mood.

And when faced with new challenges and experiences, they'll help you adapt more easily to the situation.

Healthy supplies of NGF and BDNF make you more adaptable. More resilient.

Your brain naturally generates NGF and BDNF during exercise and other healthy, pleasurable activities that activate your serotonin 5-HT2A receptors.

However, stress and aging, along with certain lifestyle factors like alcohol use, lead to a decline in their production. Mood disorders and genetics may also play a large part, too.

But it's never too late to take proactive and reactive care. Not for this special mushroom.

Here's how Lion's Mane restores vital brain chemistry, reversing the effects of stress and slowing aging. After all, age is biological, not chronological.

How This Mushroom Magnifies Memory, Mood, and Mental Dexterity | Wellness | My Supply Co.

Lion's Mane Mushrooms
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Lion's Mane improves NGF and BDNF production.

There are a lot of known studies demonstrating Lion's Mane's ability to support BDNF and NGF production. Studies also show that Lion's Mane enhances mood, decreases anxiety, and improves sleep quality, cognition, gut health, and immunity.

Here's a summary of the active brain-boosting constituents in Lion's Mane, along with their studied properties.

Bioactive ComponentTarget ProcessMechanism of Action
PolysaccharidesAntiagingEnhance Neurite Growth
Hericenones & erinacinesRegeneration of nervesStimulated Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) production
Improvement in cognitive functionsDecrease in anxiety and an improvement in quality of sleep
Microglia-mediated neuroinflammationThe improvement of antioxidant, mitochondrial function and anti-apoptosis

Find neuroprotective + nootropic Lion's Mane in Brain Stack.

Brain Stack is our master nootropic formula for optimal mental function and brain health.

+ Psilocybin Mushrooms. Boosts mood, focus, mental clarity, processing, and creativity. Breakthrough therapy for anxiety, depression, PTSD, and other mood concerns.
+ Lion's Mane. Neuroprotective. Supports memory, focus, and nerve regeneration. Also benefits gut health.
+ Sage. Neuroprotective and antioxidant. Contains choline, an essential nutrient important for memory and muscle control.
+ Cinnamon. Promotes BDNF production. Antioxidant and antiinflammatory. Enhances brain energy levels, memory, and cognitive abilities.
+ Vitamin B3. Supports cellular energy by converting fat, carbs, and protein into ATP/cellular currency. Crucial for DNA repair and optimal mood, brain function, memory, concentration, and overall cognitive well-being.

Brain Stack - Our Master Nootropic Formula. Text Reads: 5 ingredients to enhance focus, memory, and mental clarity across several major neurological systems.

Read: Three Incredible Lion's Mane Benefits For Your Brain, Gut, and Sleep

Read: How CBD Actually Improves Brain Health and Performance

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