When considering taking Balanced High or Extended Release while on antidepressants, it's essential to understand the potential risks and benefits. While serotonin Syndrome (SS) is a concern when combining drugs that increase serotonin levels, such as SSRIs and psilocybin, Kelan Thomas, Associate Professor at Touro University California College of Pharmacy, says that there is virtually no risk of SS with psilocybin due to its partial agonist properties at the serotonin 5-HT2A receptor.
Dr. Erica Zelfand, a licensed family doctor and psychedelic facilitator that works with patients taking psilocybin and antidepressants, also believes there isn't enough scientific evidence to support asking patients to discontinue their antidepressants before using psilocybin. She notes that "severe cases of serotonin toxicity with psilocybin are rare."
A recent study showed that SSRIs combined with psilocybin are safe, and SSRIs may even have a protective effect against negative drug effects like anxiety, nausea, headache, and fatigue. The study concluded that "stopping escitalopram treatment before psilocybin administration may not be warranted."
Some people on SSRIs report reduced effects of psilocybin. Dr. Zelfand found that people using SSRIs long-term might need 30-50% higher doses of psilocybin. However, Dr. Matthias Liechti, the Principal Investigator of the escitalopram study, did not see an impact on psilocybin's effects in the group taking the SSRI.
It's important to remember that experiences can vary among individuals. If you're considering taking our macrodose capsules while on antidepressants, consult a healthcare professional for personalized guidance.
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